ID A0A2G8L7M1_STIJA Unreviewed; 1170 AA.
AC A0A2G8L7M1;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 22-FEB-2023, entry version 12.
DE SubName: Full=Putative rapamycin-insensitive companion of mTOR {ECO:0000313|EMBL:PIK56268.1};
GN ORFNames=BSL78_06796 {ECO:0000313|EMBL:PIK56268.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK56268.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK56268.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK56268.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK56268.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK56268.1}.
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DR EMBL; MRZV01000181; PIK56268.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8L7M1; -.
DR STRING; 307972.A0A2G8L7M1; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 102..332
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 512..584
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 673..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1170 AA; 130131 MW; 6C474220CB5942E1 CRC64;
MGTVFLGELL HMCDRMLPVE CELHHHTLPT LMALAASLDA SILQRIRATQ AVTNLCRFHE
LKKRGPIPCS LFLDQILCNS PGYMGQRNEK INSNKPMPLT DMDESNVQAA LKDTLVLSGK
DFKEWKWDLI GSLIKRGGPS LHKFDDANIN RFFRKLMDFY KPMSHGFSSV DIGKDGSRSP
EAENYTLIGR QLIDYLLKST DAEAERLLCE LSEDIADCLL EISMAPLNSV APEAIFSTVS
VQNSLCQDYF IFVGRLSQTH RGEKILERAH AFQYMLDVCS SKVHMTLQKL IVTCLDYSRE
GLGRTVLSKV LTATSEPMRL YTTSHMRVLL RAQVPYFQHW GVENLVCQLY DKDKQVSTEA
LAVLDEACED EINLHSLVQI RPSLLHLGDH GALLLTRFLS TPKGFRYLSE VNFVQNELDK
WYSTLNRKYV ILVETEINEA FTSHKRQSAE GFLLRRSQND TKRKKDVFVP VHLYGQLVQH
KIGAELLEKQ QNVIPELCSR VHLADISSSE RLMELKSALW CLGHMGSSPL GLKLLEKMNI
IPEIIRLAEE CEVFSIRGTC FFVIGLLSKT KAGADILSSL GWESVRRTRN EFFPIANDSS
SIFDHLGRFI DHPPPISTLP SVSSFIMEQP SLPPSYASQE SAYLFPQELP VTRSPSPTNA
NFFVGEDLYE SRSSISSDER APSPLPANRV SRQDRNSGSD QLPGIQESKD NAPIEGSLNG
LKTSEAVMKI RSNSDASSRL TKDKANSEVR FSPESGNGRS SDQQSRDRSL SLKRSPPIES
SFSSLSTVAS SHTSKVFTRL THCVKATTSV GLPVTYGGSQ SQSLYPDSDF RKGGGDQRRL
HSSRDAHGYA ALKALETQRQ GSEDGDKLRR HSSLEEDGVY GSSGKSRSGS VGSIGHYTAF
LSPLKSTLKR SNAVTSNEEY IGLCLPVDVS LIFHSDESQY RGGRSSSRTS SQTSGDIPHV
QVSGPASDHP SLGSGVASSR STSSSFKDQS QAVIPAGPLL VDEENERHHP ETCIRCTKVR
AVSSLDMEKK ALSATSGRGT PNSCDTPTSV LGSFEFESGN RRVSMREDTP SGRALVRKRI
MRLVNRMASG VGLKSQEDGL LRLKERFPRS FEDPCLYSDV AQILGSRTFR LVARRFIQEL
FQDVDYEELY QEAQCILGLQ QDQAQQDKNS
//
