ID   A0A2G8L8Y1_STIJA        Unreviewed;       732 AA.
AC   A0A2G8L8Y1;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
DE   Flags: Fragment;
GN   ORFNames=BSL78_06451 {ECO:0000313|EMBL:PIK56665.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK56665.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK56665.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK56665.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK56665.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC       Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|RuleBase:RU367033}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK56665.1}.
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DR   EMBL; MRZV01000168; PIK56665.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8L8Y1; -.
DR   STRING; 307972.A0A2G8L8Y1; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.220.30; -; 2.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF41; UNC5C-LIKE PROTEIN; 1.
DR   Pfam; PF00791; ZU5; 2.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|RuleBase:RU367033};
KW   Receptor {ECO:0000256|RuleBase:RU367033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          165..245
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|Pfam:PF00791"
FT   DOMAIN          639..725
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|Pfam:PF00791"
FT   REGION          110..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         732
FT                   /evidence="ECO:0000313|EMBL:PIK56665.1"
SQ   SEQUENCE   732 AA;  83525 MW;  D7D1CF17B27A9562 CRC64;
     MVNVAQDLTL DSTLKLATLF RLPPAETDML RRVSLIDKPG ITLINFMKTR NIINMYDVTN
     LQKGLVYIQL NRTNEYHLAP YQSKVDPFQF EENQLPQLLD WPVENVKFDP DDESTSLQGS
     DEREDDHDHS KESLMDREER ELPKQTKDSQ ILEMRHHHSY IEHRIRSEGG TISIMGVHLT
     ISEGDLSFDH VIAIKVIYDP DIHLPGSARR GRMTPLIKLE PEGLTFDKPA QLTIPHSAII
     PEPDRHDVII FTGLKDEESL QEGEITWTEE KSIDWKLDPE KICLDITILS YVFVNLVNQE
     TEQKHIFRIV PFIDGILDAK DDVLITVCFC KDSDEEYKLL LADHHPKLCL GNYTTFQITR
     TLNDGSDHVS YIDLIMSSPG DGFHLMKEES TKHVDIDYLC AASRVSHQFR LTRDKDGDTD
     MVDVKLKVFQ NEMNQTALIL QSKVKNILLS PESQEILRPG LHKYEKLRGD VAKLLDKHHC
     AKLGVYFELK PAENDTIHEA AESGKMLIKI LDERELIMPN RMIGMYEGLK AIHFNKVARL
     VLEYIDTSQE KNGKENEEEK DDNKMVKIPE KQELISKSES KSSVNFTILI EEGYKRLDVQ
     RALKLSNGKL DLGRRILLLA KEEHERLPLF PGSNLYKEQY FDHRGGEMFI AGVILLIPAG
     ALHTGRIVSL WVSTEPAING PFPKKSLRLT PFVKVGPESL TLHKAVTLII PHCAFTPADH
     TGLDVYSGVL QT
//