ID A0A2G8LB85_STIJA Unreviewed; 901 AA.
AC A0A2G8LB85;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Putative receptor-type tyrosine-protein phosphatase alpha {ECO:0000313|EMBL:PIK57430.1};
GN ORFNames=BSL78_05644 {ECO:0000313|EMBL:PIK57430.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK57430.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK57430.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK57430.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK57430.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK57430.1}.
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DR EMBL; MRZV01000142; PIK57430.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8LB85; -.
DR STRING; 307972.A0A2G8LB85; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00047; PTPc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF546; TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:PIK57430.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 397..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 183..283
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 287..389
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 545..801
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 720..792
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 901 AA; 101712 MW; C3E639E7A66B7489 CRC64;
MTNITPSKEA VYIGLTLDNK VNFKKYINVT AECQAGFFGD NCTEECRCDS DACDRVTGEC
VGCCKHQWID QPQLRCQEGI IIVTGNKANP GTQWSVTCWV EELQQTPPVY TVFLSKSIGL
SSTSFPVTSN LTKDSSKAGL IQRGSTFTTT NAQAGETYYC VIQHSAGFVW LNTTLSHYEL
PMISESPEIV NMSQTSLTIN WRAWDEGTDV GDRPVVGYIV YYRKNATDSW STGTIIESSQ
LLQYTQTNLE EDTKYVFSVS AVREGDMGEG PMGPPRTVKT LCEVITNPTD VVVTVTDLNQ
LNVTWQVDDN DITCSTGITS YTIYYKVDVS SDDPQRVKTV SGSTMYTIIE RLEPGENYTF
MVSLTTDQES LLSEASMAVT FPMSSTPKPQ EDGKNNFAVQ FVIPTFFAIA LVIILITCML
IYRKRSRKAA PSSSDLTSFT NNIAIGKEDQ VSGEQSEGYE VPKDKICSLV ESGSTYEAVG
STMISKASIK RVKDNDYEDP DDIEQYAGVY INVGTAKKTA PPKPIKVSEF QDFMNRDRRN
VIEDIVKEFT VLPRGRQHPC SVALQHERLK TKNSLSKIIP YDHTRVKLQV SGNTREPDYY
NASIIKARQG IAKFIAAIGP QSKGLADTFW RMVLQQNVRT LVMLVDSPDG DVYSYWPRKV
KTTEVFGEMT VLLQEETNHQ TYSNRKLNII TDDEKLLTVH QLQFHGWPQG GVPEDYTNLI
DFIKQVKMRQ EQTSMSPMLI HCRDGSGSTG TFLALYQLLD VLRSKSTISI YNVIRNLRED
RMDMVLTRVQ YLYIYDTLQQ AQLTPEKTKT LAEELKGMDE QTLKRKAVQE FSGLSKIREL
NMPRQKQLGE AEENAYKNRF PGIIPCMYKA SNQWRAQREG QVDCQLWEDL VGDFFRFTVR
E
//
