ID A0A2G8LG24_STIJA Unreviewed; 617 AA.
AC A0A2G8LG24;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN ORFNames=BSL78_03901 {ECO:0000313|EMBL:PIK59204.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK59204.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK59204.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK59204.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK59204.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|RuleBase:RU367033}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK59204.1}.
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DR EMBL; MRZV01000090; PIK59204.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8LG24; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01670; Death; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 160..295
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 409..478
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 78..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..573
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 617 AA; 71548 MW; 9FCE49FB438B5F62 CRC64;
MRLKVEDFEE LIKFITQCKL LNKAFLNFPS PPPSLTDKTL LSSMKKNLTI EWIIGDRIVH
TLDKKSGEWP MQFRSTPHQI TDFSQPGPSK SSAHSGKKKK AEERTLTPKS GQKQDTEETG
SITTKKKHIN TGSQKIVQTP QITKILTQGE TAYQVMFKSL RVMLIVNKEG GRLDIPDTGA
SLEIPSGALE GEQLIQMIIP PHLESESLTF ASNSSLVVEL LPSNLNLMKP AILTLPHCLV
LKKGCEWKAK IYRSHHKDGS EPQWEEQSNT HYKLGEHNCV IEIQRFSWEK FEVDAQIVEA
KNIIMYAAGR CCSPDTIYLD IGYYLNLATF EENLREQMHA HVIAKLAKFQ IFRTSSSSSR
LLNLQVLISP AHQTDRKLQE REHPQRNRST RPCCPTATIQ DLSHKFCDEW RIVGSKLGIG
EPKLQTIDTD NRTAQEKVYQ MLLTWKQSKG NEATYILLGE ALQSAGRKDL QEYLYQQDLR
DQQIKFKHKN EDRERSSSKY HLEQKDVEDR EKKRVSRKRK RAKHKHHEVK RKSNSPQRKH
KHHKLKRKST SPQMERAKHK HHKFKRKSVS PQRKRAKQYQ LDNREKEHQS EEDKGQTSWR
QEKEHQSTDE EDKAIQS
//
