ID   A0A2G8LGL9_STIJA        Unreviewed;       415 AA.
AC   A0A2G8LGL9;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 4 {ECO:0000256|ARBA:ARBA00014934};
DE   AltName: Full=26S proteasome regulatory subunit RPN10 {ECO:0000256|ARBA:ARBA00044341};
GN   ORFNames=BSL78_03674 {ECO:0000313|EMBL:PIK59372.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK59372.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK59372.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK59372.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK59372.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5A family.
CC       {ECO:0000256|ARBA:ARBA00005574}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK59372.1}.
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DR   EMBL; MRZV01000084; PIK59372.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8LGL9; -.
DR   STRING; 307972.A0A2G8LGL9; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR   CDD; cd22297; PSMD4_RAZUL; 1.
DR   Gene3D; 1.10.287.3990; -; 1.
DR   Gene3D; 6.10.300.40; -; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR049590; PSMD4_RAZUL-like.
DR   InterPro; IPR003903; UIM_dom.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10223; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR   PANTHER; PTHR10223:SF0; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR   Pfam; PF02809; UIM; 3.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00726; UIM; 3.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50330; UIM; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000313|EMBL:PIK59372.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          5..188
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          231..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..245
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..351
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..391
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        392..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   415 AA;  44924 MW;  29A72FA4FCF9CE7F CRC64;
     MVLESTIVCA DTSEYMRNGD FVPTRIQAQQ DAVNLVCLSK TKSNPENNVG LIAMSPNVKV
     LVTMTSEVEI ILANLHQCHP EGSLNFLTGI KVAHLALKHR QGKNHRMRIV AFVGSPIENE
     EKELVKLAKK LKKEKVNVDI INFGQDSDNT EKLTTFINTI NGSEGTGSHL VTIPPGTLLS
     DALMHSPVIV GEDGSGAVPG LPGTGGGEFE FGFDPASDPE LAMALRISME EQRQRQEDET
     KQVIEDTAGE TTPKPTTDTD TTNNTSSNHC YSEEALLEQA LAMSMNPAAE TTSSMEEAPI
     PDFSNMTEEQ QIAYAMQMSL APDEEAETPM ETDAGGSSKT DDAKAEGGTE DYSEVMSDPT
     FLRSVLENLP GVDPSSETVQ NAMGSLLQQQ TTKDEDQRKK KGGKKDGEDK DGKKK
//