ID   A0A2G8LH09_STIJA        Unreviewed;      1251 AA.
AC   A0A2G8LH09;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Putative IgGFc-binding protein {ECO:0000313|EMBL:PIK59534.1};
GN   ORFNames=BSL78_03520 {ECO:0000313|EMBL:PIK59534.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK59534.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK59534.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK59534.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK59534.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK59534.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MRZV01000080; PIK59534.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8LH09; -.
DR   STRING; 307972.A0A2G8LH09; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   CDD; cd19941; TIL; 2.
DR   Gene3D; 2.10.25.10; Laminin; 4.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR025615; TILa_dom.
DR   InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR   PANTHER; PTHR11339:SF373; HEMOLECTIN, ISOFORM A; 1.
DR   Pfam; PF08742; C8; 1.
DR   Pfam; PF01826; TIL; 2.
DR   Pfam; PF12714; TILa; 3.
DR   Pfam; PF00094; VWD; 3.
DR   SMART; SM00832; C8; 2.
DR   SMART; SM00181; EGF; 5.
DR   SMART; SM00216; VWD; 3.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 3.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS51233; VWFD; 3.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          98..277
FT                   /note="VWFD"
FT                   /evidence="ECO:0000259|PROSITE:PS51233"
FT   DOMAIN          474..651
FT                   /note="VWFD"
FT                   /evidence="ECO:0000259|PROSITE:PS51233"
FT   DOMAIN          821..859
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          863..1045
FT                   /note="VWFD"
FT                   /evidence="ECO:0000259|PROSITE:PS51233"
FT   REGION          273..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1251 AA;  137721 MW;  D3563B903FD6418C CRC64;
     MSWFPARVPL SVSMAIPRWR VCRGLHRLPA GIGAYVKDGT VQVNEDCTES CTCVEGELQC
     APLVCDETAE CGVKGGVRGC QCKEGYTEDG ETCVEAACEC TAWGDPHYLT FDGTRHDFQG
     DCEYVLVERY TDDENDLIEP YRVVAINLKI KPTHSVSYTR GVRLETRGKT YEIQDDGTVF
     IDGIQEPLPY KDDVVTVQRL FPNKVVIDTN FQLSIIYTSR AQVKVKAFHD THLGKTRGLC
     GTCTKDPSDD FLLPSGELAT NVVEFGNAWS NGERTCDEDE GEEPCKEGSE DKKNAEDSCS
     VLSSVSDACV MDNKAEALCT NLRVYARACV DAGGDPGNWW ETVTECEPPC PVDMVYDPCG
     SACQSTCARH LADECKFLCE DVCVCPEGLM LDVDRCVPEA ECGCKIPTGG YIQQGEEVMN
     EDCSEVCRCT ETGLDCSANT CPSKATCDVK NGIRNCYCPD QYVMKDGTCE RGPCVCSVFG
     NPHFTTFDKL AYDFHGECEY ILAQKCGDSE ELPDFKLFGQ LSKNAPRDEV SYLRYLRLEL
     DGVSYEIFLG GKVKVNGRRV FLPYVDEEKG ITVGNQVFGF TTIAAKFGLF VMFDNLQKAE
     IHVHAQHAGQ TCGMCGTCTE TQSDELTLPN GQLADSVEAF GAAWRNDETC GTEDVTDNPC
     KPGSDGETQG KDLCSLLLAV PEPHSYSSLE EIATFTMCRL FMNEHDIIEK PSCFSILVGS
     LMRGRLFEIF DKALKACPDG SILIPFGEGC QPTCNDPTGQ QNCQPNTIIE TCLCQFPNIL
     HNDECINPGD CGCVSPSNYL MEDGDRYISD NCDEICHCST TGLECDPYSC DENANCELKD
     GMRNCYCRHG YSGDGQTCTG SDISASLSGD PHFLSFDSLK FDYQGSCEYT LVETCGTGEA
     LPYFELIGNF NKPRPSFKVT VTASYRLHYR GIVFEVKGAR GCFVDGAAVT LPFSRDGVTM
     TYVPRNKWLI TSDFGLVINS EFSVWQRTQY ANIVVRLPPE FTERVCGLFG SANGNRRDDL
     TMRNGQKARN CTFGNSWVTG DRECQPPEPV DPCPEGDPNR ATAIDKCWVM VDQFGPLAGC
     RDFLDPQELF DDCVYDVCLT NLETEHICKN IEAYVTLCRN RGGSPGSWWT YVPECAAPCP
     AGLEYTDCGT ACPLSCQNPD GPVECAETCI ETCQCPEGQV LDGEKCVFDY NCGCKLQNGV
     YISQGDVYTY DDCSLRCTCV DGEEKCEALV AVVPKNVRSL AQREDVSARK G
//