ID   A0A2G8LH65_STIJA        Unreviewed;       991 AA.
AC   A0A2G8LH65;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Putative A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2 {ECO:0000313|EMBL:PIK59520.1};
GN   ORFNames=BSL78_03592 {ECO:0000313|EMBL:PIK59520.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK59520.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK59520.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK59520.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK59520.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK59520.1}.
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DR   EMBL; MRZV01000081; PIK59520.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8LH65; -.
DR   STRING; 307972.A0A2G8LH65; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00041; CUB; 1.
DR   Gene3D; 2.60.120.830; -; 1.
DR   Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR045371; ADAMTS_CR_3.
DR   InterPro; IPR010294; ADAMTS_spacer1.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR   PANTHER; PTHR13723:SF281; NO LONG NERVE CORD, ISOFORM C; 1.
DR   Pfam; PF19236; ADAMTS_CR_3; 1.
DR   Pfam; PF05986; ADAMTS_spacer1; 1.
DR   Pfam; PF00431; CUB; 1.
DR   Pfam; PF19030; TSP1_ADAMTS; 7.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 7.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR   PROSITE; PS01180; CUB; 1.
DR   PROSITE; PS50092; TSP1; 8.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Integrin {ECO:0000313|EMBL:PIK59520.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          913..950
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
SQ   SEQUENCE   991 AA;  109266 MW;  3D2B70080E6413E0 CRC64;
     MFQSWRRCNG WHILREGKSG ACLVAVLKNS HYQTQSMVVG QIGEMSTVNA RELVEVECAC
     VVVIAPILDR DSGKKLCRTA EQYEACNLEP CGGNQDDFRD EQCSQTNSIP FNGQNYTWKA
     FISGQDGDDL CTKKCLSNSN FWATRPPYQY TDGTRCWHGD NSDKNTLKLC VSGKCEQFGC
     DGIQGSGQVF DACRQCNGNG ASCEQITGSF DGGRYRKHTA FLDLPVGATS IEIINVNLAY
     THMAMSSGGD SVFQGYLFTP PSSGRYGTGS NIIKYTTDFR NFRERISIQG PLTTSLTAKV
     YLLYDPHAIY GVNVKPKITY RYFVPRDQSV FEWLAGQYGE CSVTCGEGVQ TRSLRCARIE
     NGRPVEVSDS MCDQQIRPPS DMPCDGGGVS CAGAVGERIM CDAECGEGEQ TRQVECQRGD
     VLAPGECSGE RPRPSRRCNN GDCRPEPSWS VGEWSERRPV DCRRGTVLAP RACRVSGKPT
     VIQSCVMDTC PEWTVGEWSE CDAPCGIGAK NRTVECTKDG VLSEGACEGL PAPSNTQECD
     AGDCLLEAEW VFGEWSECSA DCGFGTKYRS VTCRRDSVAV QRSECSSDIK PKTKATCHRP
     PCQVPTRWTT GPWSPCSVTC GEGIQSRDIT CERDDNEVTN KNCVRDLKPS KQRTCSRDPC
     PPPSEWLSAI GQSTTCGEGV RERSVECRSG HEVTLDSNCD VNNQPETRSI CFVVECPPLP
     TWTASSWSEC TVTCGGGYQT RNVRCQRGTR SINDIECQDY DLPETRKNVT TSLALLKHLQ
     YGLPGNGMRL CSIITFLEDQ CDASCGLGVQ TRSVTCQQNG QRVPGACASQ DKPSVQRACE
     NEPCVLDAEV NAERGEYLKI KEGTKERSVC GEKSDYVLTF TDNVISIVVK TVDEDSGYAL
     SYERKDGRAS NRCDRLYVGN SGTIKSPGYP RRYPSNADCR YRIVTEPGRQ LVYPSQDSLC
     KDTTQRADMT NLRFLTFLVK HNTNIVEPEI S
//