ID A0A2G8LHN3_STIJA Unreviewed; 682 AA.
AC A0A2G8LHN3;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Retrovirus-related Pol polyprotein from transposon {ECO:0008006|Google:ProtNLM};
GN ORFNames=BSL78_03385 {ECO:0000313|EMBL:PIK59722.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK59722.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK59722.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK59722.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK59722.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK59722.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MRZV01000075; PIK59722.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8LHN3; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR46888:SF8; SCAN BOX DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46888; ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 199..212
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 399..559
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 156..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 682 AA; 77944 MW; 412507266B66F36C CRC64;
MDAYILRFER FAEEAGWSET AWATSLGALL TGKALEVYSR MPNSQAKVYS NVKSALLFKY
HLTADGFKGK FRNSRCESGE TYMQFIERLK GYIIRWIELS NSRKTYDGLI DLLLQEQLLN
SCSKDLAVFL KERALKDVSK MASLADTYTE AHVSYDRGRR KENVSDRSRS KGQGFQNQSY
KPKGDDKNAT PKLRDTRTCF ICGKSGHIAR DCWSKFKKPT ERGAGLQTGN QTEKGDKGKD
RDQFLGSTRN CVLLDGTVRI VPVAKIRIST PYFEGEVEAL CMEQPLYDLI LGNIEGCRDP
NNPDQTWVPK MIMINSEQES NEFQTKTVTG LAVETRAQKV KKEQSLKPLR VTESETLEIG
PREIKEAQHA DLSISRLWKF TKEKSAKLSR TGCRTKFVEK DGHSFQESRV DLVGPLQPLT
DKGNRYILTL VDYATRYPEA VPLQRIETER VAEALIEIFS RVGVPEEILS DMGTQFTSDL
MKEVGRLLSL KQMNTSPYHP MCNGLVEKFN GTLKRMLRRM CSERPSDWDR YLPALLFAYR
EAPQESLGFS PFELLYGRTV RGPLCILKEL WTDFRKLNKI TVFDPEPIPN PDELMTKLAT
AKYFTKIDLS KGYWQIPVQI SDRPKTAFIT SHGLFQFKVL PFGLVNAPAI FTRMMRKLLE
GQANVVNYID DVLVYTESWR NI
//
