ID A0A2G8LJ35_STIJA Unreviewed; 555 AA.
AC A0A2G8LJ35;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Putative zinc transporter ZIP12 {ECO:0000313|EMBL:PIK60273.1};
GN ORFNames=BSL78_02769 {ECO:0000313|EMBL:PIK60273.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK60273.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK60273.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK60273.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK60273.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK60273.1}.
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DR EMBL; MRZV01000061; PIK60273.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8LJ35; -.
DR STRING; 307972.A0A2G8LJ35; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR049406; ZIP4_12_EF-hand.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF30; ZINC TRANSPORTER ZIP4 N-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21116; EF-hand_Zip; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 244..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..227
FT /note="Zinc transporter ZIP4/12 EF-hand"
FT /evidence="ECO:0000259|Pfam:PF21116"
FT REGION 365..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 60607 MW; DD59DA12CCF5C0B1 CRC64;
MSQHCKLDSH HFSRTYTEVI LKTDGSPDAL TEEELEAIFD EFGHSYHSET NAKCFNVETI
FEAEVADHEA GATGEELLHM SPLMISYLLQ GYCIGEASET DPQEFLENIF EKYGHDGTIP
EEDFEAMLTS LSIGGAVEDS HGHEEDAHNH AKRSLKSHGN IDSITKREVV DDHGHGSSNG
SKVMDVSSTC FTGEDLLTIH GVDHEIGITE EQFVHLCPSL LQQILSESCN EAHEDEPKEI
SPLVWLYGSV AVFIISLGAV LGGLLLPCLP ARFFEKFIHS LIALAIAILA GDALIHLLPL
AIGIHGHESG SHVCIPLDEE LAFAWKSLAT LSAIYAFYLL ETIMDGGLIR NMLIQEYAYD
QRRRHRSRKS TSQKELTKHT DSESVDFSSE SGGCLTKYGA LPVMVIIGDG LHNFGDGLAI
GAAFTASVGA GISTSVAVLC HEIPHELGDL AILLKSGLKL KTALCLNFMS ALTSFAGLYL
GIALATTEIA RQWIFAVTAG MFLYVALADM MPQITHIKNV KDPLTTFILQ NIFFLAGAVF
IFVIAIYEDA INFSF
//
