ID A0A2G8LNX4_STIJA Unreviewed; 756 AA.
AC A0A2G8LNX4;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 22-FEB-2023, entry version 17.
DE SubName: Full=Ap-cadherin {ECO:0000313|EMBL:PIK61969.1};
GN ORFNames=BSL78_01113 {ECO:0000313|EMBL:PIK61969.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK61969.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK61969.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK61969.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK61969.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK61969.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MRZV01000021; PIK61969.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8LNX4; -.
DR STRING; 307972.A0A2G8LNX4; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027:SF422; CADHERIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 587..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..306
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 309..346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 349..525
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 695..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 279..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 336..345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 756 AA; 83125 MW; 146695BCDEC362B6 CRC64;
MGGPSAMEKL LKLLSTITGA KEENIDIFTV LPVPDMENTV DVRYSAHGSP YYSAERLNGD
AESKIALIES TLTGVTVEAI YIDECGSAEC EADCSNVLTI DPDPVVINSV EASMVGINAF
ISPFCGCAAR DGDVGTCIGH YCHNGGTCED TFSGPKPQDY ILLQLRAGKP HSNGLRCWDL
TLEVTNNGAL NDGKWHKVDI FRNGLDVELV IDDCASASVF ENHTTSVFSN SDLCKASATL
PGDETVFHAN KPLQLGGVNP NLEYPQTLGL DSVDGFNGCI RNVDQDSTLY DLYDVDEASP
GSQPGCPDAD KHCDALRPPC INGVCDADFS GAVCICNPGW FGDGCDQELD AYDFLDSSYV
TYQLKTNLPL PDRESSYKIM IRTRQQTGRV WQITNANTFE HVTMQLQDGY LMSSWHLGDN
TISVTLDKYP LDNGEWHSIF FYRYDNYIQI KVDGGGGVRQ AENRDSSFRV LQVDRDNLVV
GAELLYGVTV SSDFVGCMKD PRIGDNYLGV TETSEFASPM AVNMCHGVYL IGRCLCGRTG
LQQQSMPERC EVYDKFDDYE CCVRRDFTGK DCDLKSEAVF LTIRAGGIIP IVACLLLLLL
LLLLFIVYKR TEDKKNALAF AVDPEDDMRE NFINYDEEGG EKDQTAYDIT MLRKPVQPSP
IVPRPVKTLE DVPQRSIPRD GVNVGDFLEE RLGDLTTTRG SPYDTLHTYD YEGEGSTSGS
LSSLNSNSSD GSQDYDYLKG LGPPFKRLAD MYGGVE
//