ID   A0A2G8LR83_STIJA        Unreviewed;       446 AA.
AC   A0A2G8LR83;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Ribosome biogenesis protein NOP53 {ECO:0000256|ARBA:ARBA00018339, ECO:0000256|PIRNR:PIRNR017302};
GN   ORFNames=BSL78_00384 {ECO:0000313|EMBL:PIK62690.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK62690.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK62690.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK62690.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK62690.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- FUNCTION: May play a role in ribosome biogenesis.
CC       {ECO:0000256|PIRNR:PIRNR017302}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|PIRNR:PIRNR017302}. Nucleus, nucleoplasm
CC       {ECO:0000256|PIRNR:PIRNR017302}.
CC   -!- SIMILARITY: Belongs to the NOP53 family.
CC       {ECO:0000256|ARBA:ARBA00008838, ECO:0000256|PIRNR:PIRNR017302}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK62690.1}.
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DR   EMBL; MRZV01000007; PIK62690.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8LR83; -.
DR   STRING; 307972.A0A2G8LR83; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR011687; Nop53/GLTSCR2.
DR   PANTHER; PTHR14211; GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2; 1.
DR   PANTHER; PTHR14211:SF7; RIBOSOME BIOGENESIS PROTEIN NOP53; 1.
DR   Pfam; PF07767; Nop53; 1.
DR   PIRSF; PIRSF017302; Gltscr2; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR017302};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW   ECO:0000256|PIRNR:PIRNR017302}.
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          43..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..300
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..339
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  51944 MW;  421EDDB91B1A8C7C CRC64;
     MATKSNSKRK RFSKKNKRDW RKHSNIKDIE DFLEEQRVQE RTGGLVAEKQ DEDLFVVDNK
     SSSEKKEPEK RDKYAFRNRP LRTYENLKPN PHIPPVPKAK ARGDKLNRSA NTPRQIERMN
     GILPAREIRK LKVAAAARQK RKDVIDEEDK MNGQLPESYD LWGEGPKEVI PAKLKNADHH
     FLLYTKRVRK RVPGSYHIKS SKIDAVEIVD PGASYNPSFD DHQKLLRKAL DEEREYIKDK
     KIVDSWSKGV KKWRANELQE NYLSEMSAGL FEEEQTDGTE KKKEDGEAEE EEEVEEEEDV
     PTPNPPTTAE SRKTRQQRRK QAMIQAAVST INETGHDPSS RTAGRGAKMA KKRQNEVYRV
     KALRKEIKKQ KEKIAARREF KTPPVDFKLS TELVGSLRQI KPEGSMLRDR YKHIQKRNLM
     EARIWKSGPK RSLKDCVKRG HEEFKE
//