ID A0A2G8LRC6_STIJA Unreviewed; 1936 AA.
AC A0A2G8LRC6;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
DE Flags: Fragment;
GN ORFNames=BSL78_00278 {ECO:0000313|EMBL:PIK62827.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK62827.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK62827.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK62827.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK62827.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK62827.1}.
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DR EMBL; MRZV01000005; PIK62827.1; -; Genomic_DNA.
DR STRING; 307972.A0A2G8LRC6; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF44; PLEXIN-B; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1256..1281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..479
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1092..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PIK62827.1"
SQ SEQUENCE 1936 AA; 216653 MW; 162D6D26CB6C5983 CRC64;
CTTDISIYHT YADDPVGPIA KXKMKGFPFR GPELLSLFIT FILLTKADCE PHVNDADHYL
VESFQSHQNY NRTLTLLKVH ADKVYVAGNN ALFYLLEDLQ LDQSQLSYEE ENIYKILETS
ASQEKIFTCG SAGDGGCEYR PLDDIDQVSS VENVEEVVSP YTTVGVIAPG EESESESLYI
ARGVKKSPAK APIIEIDLQT LQQNRATSII SSSAKDSFLI HYSGTFFYNG FVYFLSSRRK
NANEEESRII PKLTRLCVKD ETDTLDAFTE VELACEGKDS KVYSIAQASY LLDDKLFIVF
TENIDPEYEL NPGTQSALCV YDMGHLEETF RAAVKACACG YKNASHSNSL QFSNCFTGGV
DICQNQEVVD RLTCGIIGSI FKYPEQHKDD KVIEYAILEQ GNATFSSVVV AQLPSDRNHT
IAFIGTDQGT LLKANLNGAD SIVYEVVDVS APVLADTTLV DDNENLLVLT NETVLKMSVI
DCSQFSTCEE CIRPDTLFGD PSCGWCTLKK SCTRYLDCAS NEVPGRWLPY DEETCAAITS
VTPPSLAIEE DEQIINLTVA HLPALAEGQS YECRFNENRI PATVNESTLE CRSPTRDQLP
EVVAGDSVTV KLHIYSSETD MNFLTTDYRF YSCGAIKSCS KCVKNEWECD WCKFEHRCTH
DSLSCIDDKI IYGAYNSQNA STAADSCPQI MPQDTKLIPT EVPQTLSFQA KNLPPLDGPN
GRVTRYSCQL KTMNPPDIEV GYMADATLKT HDNITFNVTC EEQEYTYSKD MQYLNTSLTL
KWNTGNMVDL SQPVRLYKCS SMRPDCSRCL STETTPAELS CVWCSSSNKC EAAAKCTNRR
EPGQSCPAPK IDTVEPKTSP LGGGTRVTLT GSNLGRNITD IKSITLVDVP CTLIEDTFKV
GESIACEAGE SPEEKGGSAV IVVAEQDVAS RDEQRDELLN SFNYKDPTTS NFEPKRGPFS
GGTTVKITGK KLDVGTEVEV NMGRVPCKFV NRTADYIYCE TEDAKQEEVD ADALELGVTV
TFEGSTNKTV PGKFSFELDP EVTAIEPLKA IRAGGIQLTV TGERFDLIQS PRIIAKRDED
IISEMLCSPN ASDPAKKMTC PSPTIPKEGS RKRRQADGDS IKDVVIGFIL DGVTSQENWT
RDNGFVFEFF PDPNYEPFKD SELKFKHGMD TPLEILGSNI DTATNPEEIK VFVGPKECVI
QLIAERVIHC TPPENQPAAE FYNGSKTDRG LPYVTVKHGT ILVFDIGYVR YVTDPALYII
ICICGLLILI VCIALIIIYC LRKSKNKEVE RLIMELTNVR TNISEELREL FAMLQTAMDK
FETNPEGLPV LPLTDRSEYV KNMLFLNLNE QPTTEQPMVS ETVDAMKKFS ELISNKSFLL
VFIRTLDKEK NLPMMDRVNI ASLITLALLL EGKLDYLTDV MMTLMSEEIE DIVEKGRPRQ
LFRRNESIVE KLVSNWVAIC LYDYLETAGA EKIVQLYGAI QCVIEKGPID AVSRKSQFSL
SDEHMLDAHI QFDEVNLQVV ANEEDGEIAS VTVLNVDTIT QVKNKILDHL NRGRPYSARP
IASDMDLEWR QGVSGQLVLR DEGADSEVKD GWKKINTLKD YRVGDDCRVA LIRKQAHPNA
QLANRSDIVA RGGTVADMSE ISETSFLQRC FCTCCIETKG GIQEANDIAE KVPLHRSPTL
VEATIEEGVN LWHLIKETEG SDDIQHKSKN KRRLQKKGIK EVLLPLLPAT RNALQKYVDG
AFRVMLSDEE SQVPKCIKYL FDFFDRQATK NSVDGPEVVN AWKNNVLPLR FWTTIMANPT
YIFDVRRSSY VEACLRVLVQ VLRDACSKSD FKLNKDSSPS RLLYASLLPT YTAQVEKYYK
RIQDIPRLKP DDIKEEFARI CKPFENIFDR DSTMFQLYKF ANKFNESLNA ALEEDDDCQN
ANLVYRMEQV GITLNE
//
