ID A0A2G8LRF4_STIJA Unreviewed; 1311 AA.
AC A0A2G8LRF4;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 22-FEB-2023, entry version 18.
DE RecName: Full=MIF4G domain-containing protein {ECO:0000259|SMART:SM00543};
GN ORFNames=BSL78_00280 {ECO:0000313|EMBL:PIK62829.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK62829.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK62829.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK62829.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK62829.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK62829.1}.
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DR EMBL; MRZV01000005; PIK62829.1; -; Genomic_DNA.
DR STRING; 307972.A0A2G8LRF4; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 4.
DR Gene3D; 4.10.80.160; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR039762; Nmd2/UPF2.
DR InterPro; IPR007193; Upf2/Nmd2_C.
DR PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR Pfam; PF02854; MIF4G; 2.
DR Pfam; PF04050; Upf2; 1.
DR SMART; SM00543; MIF4G; 3.
DR SUPFAM; SSF48371; ARM repeat; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 182..463
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 586..756
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 771..986
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT REGION 1..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1225..1255
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 46..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..572
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1122
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1311 AA; 151268 MW; 9543CBD655A530C2 CRC64;
MTKDEKSRGA KEGATADTPA AKKSTDKDTK RASNGSMQKV TKGGETGSSD ARKDYKTSSK
EGDHDKKRSL TKDELAKLEQ EKRRINEEER KKREDDKKRK EEEKKRKEEE AKIDEERKKE
EEQKRQEEEA KMREEEEKKN AAEMYKESVE RKEIKRLTRD KNLSAAENRP DEDFFVRKDS
SLKKNTAFVK KLKTLTESQR ESLSKEFEGL NLTKYISEAA TSISEAKIKM ADIPCAIYMA
SLMHRRYVDF AAHLLDAIQR SLPVLMKKDE KDKNIVTFDP RIRLQLRLLA ELIVHGIFTE
KEGLPLLNNA LATILKSDRR TTRTSQLSSA SPSTAERTLQ ASPQERATQK YGHELLTSEV
VSPQPKTAYR HLLKDHFIVL SKHLKDEHKA LKNLERHSRK ILQTKGELST ERRKTLEETQ
TAFQKLQINT SNFSDLIDED MPDLPKDEVD EDDLLTIDFL HPEKNMADFD FENSRWEDED
TRTFHENLID LRTMVPAILF KNCAKIKTPE ETSSAEDMKK LEEGRKATAE GEEDPSLPLE
AEMVVEEVEP EEDQVLEEDQ EGEVEQEGEA EDGETNPNMS MKVMLDTFLQ KLPTCINRDF
IDKAAVEFCM NLNTKANRKR LVQCLVDVPR QRLDLLPFYS RLVATLHSCM SDVATNLADK
LKMNFRYHLR KKDQMHIESK IKTVRFIVSF TGLRHHNIDM ACAVLETCGR FLYRTADSHL
RVKILLDMMM RKKSRMPLDD RHNTMIENAF YYCNLQRSKK QRGRYVPRCT NTYRKLLFKD
LSKNMVEKVL KQMRKLDWTD QKVKLYAMKC LSSVWNIKFG NIHCMANLVA GLVSYYDNVG
IYVVDGVLED IRAGMEINHP KFNQRRVSMV KFLGELYNYK MVESTVIFRV LYSFIRVGVS
LDANNPTPFD PPDHLFRIRL VCTLLDTCGH FFDRGNSKKR LDCFLIYFQQ YYFFKKSLPV
FDPEARPFPL DCDNAVMDTV ECLRPKLKFY ADIEEANQAV ADLKRDCLQK LSEKVPPEQL
AAFQQQMNQS NDTTGYPNLP SIMEGDENES EDFVRTPAGF SDMLEDDEDS DSVMEVDADG
DGFNSAPNSQ SQLTGEEETA DDVDGMDEDE DLPEESAGET EEDDQMAVIK GAPKLINCEE
DDDFSSEYEK LMAETYQRTV ETSKVPQLDI GVPVLHKPTP KKLTFSSMQP LQEEEKNTMN
FTLMTKKGNK QQLKAFEVPI DSTLVTNLKN REEAEQAEKQ RLKKLTLDIN ERQEEEDYQE
MLATLQRPAT TVIPRDTSKP RFNHPKGAPD VNDIFNAKGN RCEEKKLSCN Q
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