ID A0A2G8RHV3_9RHOB Unreviewed; 880 AA.
AC A0A2G8RHV3;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=P775_06340 {ECO:0000313|EMBL:PIL21164.1};
OS Puniceibacterium antarcticum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Puniceibacterium.
OX NCBI_TaxID=1206336 {ECO:0000313|EMBL:PIL21164.1, ECO:0000313|Proteomes:UP000231259};
RN [1] {ECO:0000313|EMBL:PIL21164.1, ECO:0000313|Proteomes:UP000231259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM1211 {ECO:0000313|EMBL:PIL21164.1,
RC ECO:0000313|Proteomes:UP000231259};
RA Zhang X.-Y., Liu C., Chen X.-L., Xie B.-B., Qin Q.-L., Rong J.-C.,
RA Zhang Y.-Z.;
RT "Genome sequencing of Phaeobacter antarcticus sp. nov. SM1211.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIL21164.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AWWI01000047; PIL21164.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8RHV3; -.
DR Proteomes; UP000231259; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000231259}.
FT DOMAIN 704..720
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 840..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 630..637
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 880 AA; 95041 MW; 9561BC6CF698B3A5 CRC64;
MNAVTPMMAQ YQEIKAQYKD ALLFYRMGDF YEMFFDDAVA ASAALDIALT KRGKHDGDDI
PMCGVPVHSA EGYLLTLIRK GFRVAVCEQM ESPAEAKKRG GKSVVKRDVV RLVTPGTLTE
ESLLEARRHN YLAALSNVRD AWALSWCDIS TGVFHVMSLS QARIGAELAR LAPSEVLVSD
AVDEILREVL GDLGILPTVL GRASFDSTGS EARLCGLFGV ASLDAFGRFE RVEVSAMGAL
VDYLDITQKG KLPLLQPPRQ DQVTRLMQID AATRRNLELT HALNGGRAGS LLSVIDRTVT
SGGARLLERR LSSPSRELSV VLARQGAVAW CLSSVDVSLF LRESLKRVPD LDRALSRLGL
DRGGPRDLVA VRIALEQAER IAGRLDGEDL PEHLAHACKD LGGHHALVTL LGDALNAEPP
LLVRDGGFIA EGYDAALDEA RTLRDEGRSV IARMQAEYAA LAGVSGLKIK HNNVLGYFIE
TTATHAEKML SSPLSETFIH RQTTANQVRF TTVELSEIET KILNAGGEAI EIEKRLYDGL
KGSILERAAE ISLTALALAE FDLACGMADL AAAQDWCRPV VDESRAFDIE GGRHPVVERA
LAAQGGAPFI ANDCDLSPES DAAAVQLLTG PNMAGKSTYL RQNALIALLA QMGGYVPASS
AHIGLVSQIF SRVGASDDLA RGRSTFMVEM VETAAILNLA DDRALVILDE IGRGTATYDG
LSIAWATLEH LHEVNRVRGL FATHYHELTV LAGKLPGVSN ATVAVKEWDG EVIFLHEVRP
GAADRSYGVQ VAQLAGLPAS VIKRARHVLE QLEKGEREKV SPKALIDDLP LFSVMAREPA
PAPKAASSDV EDRLATLSPD EMTPREALQA LYDLKGLLRA
//
