ID A0A2G9GLN8_9LAMI Unreviewed; 814 AA.
AC A0A2G9GLN8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Cucumisin {ECO:0000313|EMBL:PIN06173.1};
DE EC=3.4.21.25 {ECO:0000313|EMBL:PIN06173.1};
GN ORFNames=CDL12_21273 {ECO:0000313|EMBL:PIN06173.1};
OS Handroanthus impetiginosus.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Bignoniaceae; Crescentiina; Tabebuia alliance;
OC Handroanthus.
OX NCBI_TaxID=429701 {ECO:0000313|EMBL:PIN06173.1, ECO:0000313|Proteomes:UP000231279};
RN [1] {ECO:0000313|Proteomes:UP000231279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. UFG-1 {ECO:0000313|Proteomes:UP000231279};
RX PubMed=29253216; DOI=10.1093/gigascience/gix125;
RA Silva-Junior O.B., Grattapaglia D., Novaes E., Collevatti R.G.;
RT "Genome assembly of the Pink Ipe (Handroanthus impetiginosus,
RT Bignoniaceae), a highly valued, ecologically keystone Neotropical timber
RT forest tree.";
RL Gigascience 7:1-16(2018).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIN06173.1}.
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DR EMBL; NKXS01004506; PIN06173.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G9GLN8; -.
DR STRING; 429701.A0A2G9GLN8; -.
DR OrthoDB; 560611at2759; -.
DR Proteomes; UP000231279; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02120; PA_subtilisin_like; 1.
DR CDD; cd04852; Peptidases_S8_3; 1.
DR Gene3D; 2.60.40.2310; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034197; Peptidases_S8_3.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR InterPro; IPR045051; SBT.
DR PANTHER; PTHR10795; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN; 1.
DR PANTHER; PTHR10795:SF607; SUBTILISIN-LIKE PROTEASE SBT1.7; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000231279};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..814
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013560507"
FT DOMAIN 29..111
FT /note="Inhibitor I9"
FT /evidence="ECO:0000259|Pfam:PF05922"
FT DOMAIN 134..562
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 357..445
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT ACT_SITE 143
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 200
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 526
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 814 AA; 88568 MW; 916E3172AD3FA9D6 CRC64;
MSQVPILSLI VTLILQLSSA NANDSSLQTY IVHVDLPDIQ LLSEQSQDLE SWYNSFLPTT
IATSTETSRM AYSYRNVFSG FAAKLTCEGV KSMQEKKGFI SARPQQILPL HTTHTPNFLG
LHQNMGFWKQ SNYGNGIIIG VLDTGIFPNH PSFNDEGMPP PPPKWKGPCE FNFTGACNNK
LIGARHFRNG DGTPLDFDGH GTHTAATAAG NFVRGANLSG LANGTAVGIA PLAHLAMYKV
CSPGCSESDI LAAMDAAIED GVDVLSISLG GPSRPFHEDN IALGAFSAME KGIFVSSSAG
NYGPFNLSLA NEAPWILTVG ASTTDRKLMA TAVLGNNQEL NGESAFQPKD FANTQLSLVY
PGSNVSDFNA VYCSKTSLDN VDAQGKIVLC QVGGRMTSVE KGRAVRDAGG AAMILINPKS
RAHSTFADAH VIPATNLNYE DGLRILAYVN STSTPTASIV FKGTITGDKN SPVVASFSSR
GPSRSSPGIL KPDIIGPGVN ILAAWHLSVE NNANTKSNFN IISGTSMLCP HLSGVAALLK
SAHPDWSPAA IKSAIMTTAD TMNLQNEPIL DERHLPADIF ATGAGHVNPA RANDPGLIYD
IEPREYLPYL CGLNYTQRQI FAVLQHRVNY TAESRIPEGQ LNYPSFSFRP GLSHQTFDTN
SDKCWGATIL NFSELNQKLS FEVTFRRLGN AANTTVSQGY ILWKSANFCD VMILGITIKI
TTRKLGNSDE KFRRTKGRRR IPTKFPTELD GIHEIWENKF SDGISVGKYI GRKIRRKIVR
RNFCRKLVPT SIFPTNIGRR KFYNFENVLR VTKE
//
