ID A0A2G9P6B0_9ARCH Unreviewed; 103 AA.
AC A0A2G9P6B0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=phosphoribosyl-AMP cyclohydrolase {ECO:0000256|ARBA:ARBA00012721};
DE EC=3.5.4.19 {ECO:0000256|ARBA:ARBA00012721};
GN ORFNames=COT90_02130 {ECO:0000313|EMBL:PIN98874.1};
OS Candidatus Diapherotrites archaeon CG10_big_fil_rev_8_21_14_0_10_31_34.
OC Archaea; Candidatus Diapherotrites.
OX NCBI_TaxID=1974406 {ECO:0000313|EMBL:PIN98874.1, ECO:0000313|Proteomes:UP000230773};
RN [1] {ECO:0000313|EMBL:PIN98874.1, ECO:0000313|Proteomes:UP000230773}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CG10_big_fil_rev_8_21_14_0_10_31_34
RC {ECO:0000313|EMBL:PIN98874.1};
RA Probst A.J., Ladd B., Jarett J.K., Geller-Mcgrath D.E., Sieber C.M.,
RA Emerson J.B., Anantharaman K., Thomas B.C., Malmstrom R., Stieglmeier M.,
RA Klingl A., Woyke T., Ryan C.M., Banfield J.F.;
RT "Depth-based differentiation of microbial function through sediment-hosted
RT aquifers and enrichment of novel symbionts in the deep terrestrial
RT subsurface.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-
CC D-ribosyl)-5-[(5-phospho-beta-D-
CC ribosylamino)methylideneamino]imidazole-4-carboxamide;
CC Xref=Rhea:RHEA:20049, ChEBI:CHEBI:15377, ChEBI:CHEBI:58435,
CC ChEBI:CHEBI:59457; EC=3.5.4.19;
CC Evidence={ECO:0000256|ARBA:ARBA00000024};
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
CC {ECO:0000256|ARBA:ARBA00005169}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIN98874.1}.
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DR EMBL; PFAI01000022; PIN98874.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G9P6B0; -.
DR UniPathway; UPA00031; UER00008.
DR Proteomes; UP000230773; Unassembled WGS sequence.
DR GO; GO:0004635; F:phosphoribosyl-AMP cyclohydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.10.20.810; Phosphoribosyl-AMP cyclohydrolase; 1.
DR InterPro; IPR002496; PRib_AMP_CycHydrolase_dom.
DR InterPro; IPR038019; PRib_AMP_CycHydrolase_sf.
DR PANTHER; PTHR42945; HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR42945:SF1; HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HIS7; 1.
DR Pfam; PF01502; PRA-CH; 1.
DR SUPFAM; SSF141734; HisI-like; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Histidine biosynthesis {ECO:0000256|ARBA:ARBA00023102};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:PIN98874.1}.
FT DOMAIN 27..100
FT /note="Phosphoribosyl-AMP cyclohydrolase"
FT /evidence="ECO:0000259|Pfam:PF01502"
SQ SEQUENCE 103 AA; 11936 MW; B0F8D231C58C6819 CRC64;
MKKIDWNKGN GLIPTIVQEE TNSEVLMLAY STKESLEKAM KTSQGWYYSR SRKKLWRKGE
TSGNTQKLKK VFVDCDKDTL LFKVEQTGNA CHLNKKNCFK VLK
//
