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Database: UniProt
Entry: A0A2G9SLQ9_LITCT
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ID   A0A2G9SLQ9_LITCT        Unreviewed;       255 AA.
AC   A0A2G9SLQ9;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
GN   ORFNames=AB205_0018070 {ECO:0000313|EMBL:PIO40982.1};
OS   Lithobates catesbeiana (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana;
OC   Aquarana.
OX   NCBI_TaxID=8400 {ECO:0000313|EMBL:PIO40982.1};
RN   [1] {ECO:0000313|EMBL:PIO40982.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bruno {ECO:0000313|EMBL:PIO40982.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:PIO40982.1};
RA   Warren R.L., Vandervalk B.P., Kucuk E., Birol I., Helbing C.,
RA   Pandoh P., Behsaz B., Mohamadi H., Chu J., Jackman S., Hammond S.A.,
RA   Veldhoen N., Kirk H., Zhao Y., Coope R., Pleasance S., Moore R.,
RA   Holt R.;
RT   "Assembly of the North American Bullfrog Genome.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|SAAS:SAAS00595019}.
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DR   EMBL; KV923612; PIO40982.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00138218};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00138186};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    255       Receptor protein serine/threonine kinase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013722119.
FT   TRANSMEM    103    128       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      159    188       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      189    255       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   255 AA;  28992 MW;  183D01410EF48095 CRC64;
     MLHKILWMIL LWTVPSVTDI TSYNCTCEGG HCSENTCNGK TCFVTEQLLE NNEIRRVRGC
     FNSDITEQCN SKTSFSEARC CYSNFCNADI TIYTIKNKVE EPVGLVLVTV LPVALFLILA
     ILFTFLFWKL RRKSRKKSLA RLIDFGNEDI VNASTVGDST LGDLLDDYCT TGSGSGLPFL
     VQRTVARQVT LVECVGKGRY GEVWRGTWQG ENVAVKIFSS RDEQSWFRET EIYNTVLLRH
     ENILGNVQLL YFINY
//
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