ID   A0A2G9U352_TELCI        Unreviewed;       422 AA.
AC   A0A2G9U352;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Papain family cysteine protease {ECO:0000313|EMBL:PIO64663.1};
GN   ORFNames=TELCIR_13698 {ECO:0000313|EMBL:PIO64663.1};
OS   Teladorsagia circumcincta (Brown stomach worm) (Ostertagia circumcincta).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae;
OC   Teladorsagia.
OX   NCBI_TaxID=45464 {ECO:0000313|EMBL:PIO64663.1, ECO:0000313|Proteomes:UP000230423};
RN   [1] {ECO:0000313|EMBL:PIO64663.1, ECO:0000313|Proteomes:UP000230423}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S {ECO:0000313|EMBL:PIO64663.1,
RC   ECO:0000313|Proteomes:UP000230423};
RA   Mitreva M.;
RT   "Draft genome of the parasitic nematode Teladorsagia circumcincta isolate
RT   WARC Sus (inbred).";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KZ349694; PIO64663.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G9U352; -.
DR   Proteomes; UP000230423; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:PIO64663.1};
KW   Protease {ECO:0000313|EMBL:PIO64663.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230423}.
FT   DOMAIN          220..415
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
FT   REGION          144..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   422 AA;  48065 MW;  06BD66E3B780E81B CRC64;
     MSALWLVDIA RISVRGPWVY DHCLLGLASK VRHRTDGGLC DKEVRKKVTK EEVQRSDGSG
     KKFPYILNET PHIAKCSFCP IKFFPTSVSQ QAADHFTTEN ASWLNFPSIA LRATNHLLSF
     DKLPEPVKSV EKEQVEEVEG ELLDEITQSE HHKKSQKDKI DWPSVSEEEV SEEDESESMD
     EKIPNMLDEP RESDDEVVVH GEGEESLEEV TSQRKNLLIA PVRRGLLKSQ QGTTETDETV
     TQNERHHRYG GLKRSGKVFE HKRDVHFFII WIYILKAANE IIDCNGKGNC QGGEVGDVLE
     YAKTHGLVEE GCNVYRATNG HCDPFHRCGT CWPDSCTAAK NYTRYYVKEY GKPNHIVSVT
     GWGVDENGVE HWIVRNSWGE EWGEKGWYRV VTSTYKNGTG DEYNMGIERE CYYADVDVSN
     LD
//