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Database: UniProt
Entry: A0A2H0ZC81_CANAR
LinkDB: A0A2H0ZC81_CANAR
Original site: A0A2H0ZC81_CANAR 
ID   A0A2H0ZC81_CANAR        Unreviewed;       562 AA.
AC   A0A2H0ZC81;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=MATE efflux family protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=B9J08_004944 {ECO:0000313|EMBL:PIS48259.1};
OS   Candida auris (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC   Candida/Metschnikowiaceae.
OX   NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS48259.1, ECO:0000313|Proteomes:UP000230249};
RN   [1] {ECO:0000313|EMBL:PIS48259.1, ECO:0000313|Proteomes:UP000230249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B8441 {ECO:0000313|EMBL:PIS48259.1,
RC   ECO:0000313|Proteomes:UP000230249};
RX   PubMed=27988485; DOI=.1093/cid/ciw691;
RA   Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA   Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA   Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA   Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT   "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT   continents confirmed by whole-genome sequencing and epidemiological
RT   analyses.";
RL   Clin. Infect. Dis. 64:134-140(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIS48259.1}.
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DR   EMBL; PEKT02000010; PIS48259.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H0ZC81; -.
DR   STRING; 498019.A0A2H0ZC81; -.
DR   EnsemblFungi; B9J08_004944-t37_1; B9J08_004944-t37_1-p1; B9J08_004944.
DR   VEuPathDB; FungiDB:B9J08_004944; -.
DR   VEuPathDB; FungiDB:CJI96_0003734; -.
DR   VEuPathDB; FungiDB:CJI97_005028; -.
DR   VEuPathDB; FungiDB:CJJ07_003238; -.
DR   VEuPathDB; FungiDB:CJJ09_004419; -.
DR   VEuPathDB; FungiDB:CJJ09_004477; -.
DR   VEuPathDB; FungiDB:QG37_01043; -.
DR   OMA; AAWFELF; -.
DR   Proteomes; UP000230249; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   CDD; cd13132; MATE_eukaryotic; 1.
DR   InterPro; IPR045069; MATE_euk.
DR   InterPro; IPR002528; MATE_fam.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR11206:SF153; ETHIONINE RESISTANCE-CONFERRING PROTEIN 1; 1.
DR   PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR   Pfam; PF01554; MatE; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230249};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        99..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        244..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        278..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        435..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        472..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        500..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   562 AA;  62224 MW;  FC660B784F226CA7 CRC64;
     MDERSHLLHE HTPEVDDEGI VAYVQQRRAS IASAGPASIP AVFQLSSKQS RESFADIHRT
     VSHVSHYDSV NELLSVHSGH LLEEPHTSLF MEIRALLKYS VPLVVTFLLQ YSLTVASVLS
     VGRLGPSELA AVSLSSMTAN ISGYAIIQGV STCLDTLCAQ AHGRKDFNTV GMHFVRCTYL
     LMLCFVPMFV LWVFLSQPLL LMLVGEKKRH LVALASRYLR ILSFGLPGFI IFENLKHFLQ
     SQGIFHASTF VLIFCAPMNA VLNYVLVWNK HIGLGFEGAP LSVVITNWVM CLALWCYTKY
     VNGYACLPRQ GVIHKSYFTN WRRMINLSIP GVSMVEAEWL AFEIITFVAF TFGTEVSAAQ
     SIVSTTCVLL YQIPFALSIT ASTRIAWFIG AASESSALVA TRAALYAAVC LGLVNATILF
     FFREFFASLF TNDKYVIRIA SKVLIVGALY QINDFISCTT GGILRGQGRQ KIAGYLNVIS
     YYLIALPSAL FFAFHFKLEL LGLWLGMIIA LFFVSVSQLY FVATSDWDHI IKECIEEGVA
     EDGVLNIEAT SSVPAMSSSH LV
//
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