ID A0A2H0ZC81_CANAR Unreviewed; 562 AA.
AC A0A2H0ZC81;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=MATE efflux family protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=B9J08_004944 {ECO:0000313|EMBL:PIS48259.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS48259.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS48259.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS48259.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIS48259.1}.
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DR EMBL; PEKT02000010; PIS48259.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZC81; -.
DR STRING; 498019.A0A2H0ZC81; -.
DR EnsemblFungi; B9J08_004944-t37_1; B9J08_004944-t37_1-p1; B9J08_004944.
DR VEuPathDB; FungiDB:B9J08_004944; -.
DR VEuPathDB; FungiDB:CJI96_0003734; -.
DR VEuPathDB; FungiDB:CJI97_005028; -.
DR VEuPathDB; FungiDB:CJJ07_003238; -.
DR VEuPathDB; FungiDB:CJJ09_004419; -.
DR VEuPathDB; FungiDB:CJJ09_004477; -.
DR VEuPathDB; FungiDB:QG37_01043; -.
DR OMA; AAWFELF; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206:SF153; ETHIONINE RESISTANCE-CONFERRING PROTEIN 1; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230249};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 562 AA; 62224 MW; FC660B784F226CA7 CRC64;
MDERSHLLHE HTPEVDDEGI VAYVQQRRAS IASAGPASIP AVFQLSSKQS RESFADIHRT
VSHVSHYDSV NELLSVHSGH LLEEPHTSLF MEIRALLKYS VPLVVTFLLQ YSLTVASVLS
VGRLGPSELA AVSLSSMTAN ISGYAIIQGV STCLDTLCAQ AHGRKDFNTV GMHFVRCTYL
LMLCFVPMFV LWVFLSQPLL LMLVGEKKRH LVALASRYLR ILSFGLPGFI IFENLKHFLQ
SQGIFHASTF VLIFCAPMNA VLNYVLVWNK HIGLGFEGAP LSVVITNWVM CLALWCYTKY
VNGYACLPRQ GVIHKSYFTN WRRMINLSIP GVSMVEAEWL AFEIITFVAF TFGTEVSAAQ
SIVSTTCVLL YQIPFALSIT ASTRIAWFIG AASESSALVA TRAALYAAVC LGLVNATILF
FFREFFASLF TNDKYVIRIA SKVLIVGALY QINDFISCTT GGILRGQGRQ KIAGYLNVIS
YYLIALPSAL FFAFHFKLEL LGLWLGMIIA LFFVSVSQLY FVATSDWDHI IKECIEEGVA
EDGVLNIEAT SSVPAMSSSH LV
//