ID A0A2H0ZDP7_CANAR Unreviewed; 477 AA.
AC A0A2H0ZDP7;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Aminopeptidase P N-terminal domain-containing protein {ECO:0000259|SMART:SM01011};
GN ORFNames=B9J08_005446 {ECO:0000313|EMBL:PIS48744.1}, CA7LBN_003372
GN {ECO:0000313|EMBL:QWW24515.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS48744.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS48744.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS48744.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS48744.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS48744.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QWW24515.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA7LBN {ECO:0000313|EMBL:QWW24515.1};
RA Finianos M.;
RT "Candida auris outbreak in lebanese hospital.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; PEKT02000010; PIS48744.1; -; Genomic_DNA.
DR EMBL; CP076752; QWW24515.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZDP7; -.
DR STRING; 498019.A0A2H0ZDP7; -.
DR EnsemblFungi; B9J08_005446-t37_1; B9J08_005446-t37_1-p1; B9J08_005446.
DR VEuPathDB; FungiDB:B9J08_005446; -.
DR VEuPathDB; FungiDB:CJI96_0004782; -.
DR VEuPathDB; FungiDB:CJI97_005529; -.
DR VEuPathDB; FungiDB:CJJ07_002961; -.
DR VEuPathDB; FungiDB:CJJ09_003898; -.
DR VEuPathDB; FungiDB:QG37_06740; -.
DR OMA; YVTDCDL; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR Proteomes; UP000825438; Chromosome IV.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01087; Prolidase; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000994; Pept_M24.
DR PANTHER; PTHR43226; XAA-PRO AMINOPEPTIDASE 3; 1.
DR PANTHER; PTHR43226:SF1; XAA-PRO DIPEPTIDASE; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SMART; SM01011; AMP_N; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000230249}.
FT DOMAIN 14..151
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|SMART:SM01011"
SQ SEQUENCE 477 AA; 55096 MW; 3E5D2BE78E042941 CRC64;
MSTEGPASLK GKKYPAKEHN TRVLSHFKEK KSLKSAETLA FFMSGEDLEL WQYCDQTKPI
RQNRYFYYLS GVEIPGSHVL FDAANDKLTL FLPDIDYDDV MWSGMPLSPE EALKKYDVDE
VKYAADLEKV VGALAEAKYT IHTTDHNKWN KRVSHLLTEQ DPDFFHALDE ARLIKDWYEI
ELMRHASAIT DKCHLAVMSA TPIESNETHI HAEFMYHALR QGSKYQSYDP ICCSGPNCST
LHYVKNDDEI DNKRSVLIDA GAEWSCYASD VTRCFPINGD WTEEHLTIYN LVLDMQRKTM
DMIKPGAHWD EIHLTAHRVM IKEFLRLGIF KKEYSEEEIF ESSISARFFP HGLGHVLGMD
THDVGGRPDY NDPDPKLRYL RLRRELKEGM VLTDEPGVYF SPFLLKDVLE DPKKAKYINK
DVLAKYWYIG GVRIEDDLLI TKDGFENFTK ITSDPHEISK IIKESSAQGK ERFHNVV
//
