ID A0A2H0ZDZ1_CANAR Unreviewed; 855 AA.
AC A0A2H0ZDZ1;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Integral membrane protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=B9J08_005522 {ECO:0000313|EMBL:PIS48816.1}, CA7LBN_003306
GN {ECO:0000313|EMBL:QWW24449.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS48816.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS48816.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS48816.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS48816.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS48816.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QWW24449.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA7LBN {ECO:0000313|EMBL:QWW24449.1};
RA Finianos M.;
RT "Candida auris outbreak in lebanese hospital.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; PEKT02000010; PIS48816.1; -; Genomic_DNA.
DR EMBL; CP076752; QWW24449.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZDZ1; -.
DR EnsemblFungi; B9J08_005522-t37_1; B9J08_005522-t37_1-p1; B9J08_005522.
DR VEuPathDB; FungiDB:B9J08_005522; -.
DR VEuPathDB; FungiDB:CJI96_0004708; -.
DR VEuPathDB; FungiDB:CJI97_005603; -.
DR VEuPathDB; FungiDB:CJJ07_003505; -.
DR VEuPathDB; FungiDB:CJJ09_003807; -.
DR VEuPathDB; FungiDB:CJJ09_003808; -.
DR VEuPathDB; FungiDB:QG37_07107; -.
DR OMA; PKRYYAH; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR Proteomes; UP000825438; Chromosome IV.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF26; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230249};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..161
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 184..362
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 373..646
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 766..854
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT COILED 284..311
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 715..742
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 855 AA; 97365 MW; 77E509BD08A7677C CRC64;
MADADTQSTS TSAVLVTLVS NSILLGCFVG GFLILRLKFK RIYSPKSSFD LVPEEKKPEP
LPLDPVRWIF VLLTKPHSFI LQQCGMDGYF FLRYLIMCAM TFLGGMLIWV ILLPINATNG
NGHDGLDQLS FANVKHHRRY YAHAFMSWFF YGGVIYMIYR ELFFYNSLRA AVLSSPRYAN
KLSSRTVLFQ SVPDAFLDEK QFVKLFNGVK RIYVSRNVRR LAYKVRQREA FAMQLEAATT
QLLVKAMKAK KKMDKKGVQV EDPEDINSYV PEKKRPRCKE GGFFSKKVDK IEYLRNKLQE
LDEEVKKHQK KYRMANPKNT LFVEFEDQFS AQLAYQSVVH HTPMRMTPAY IGYDPADIDW
DNMRLFWWER ITRKLIASAA IIALIIFWAI PVAFVGVISN INNLTEKLPW LGWIQNLPDW
LLGVVTGLLP TIMLSLLMTL LPMFIRGMAK IAGCVSFQHT EDFTQNCYFG FLTVNSFLVT
ALASSATAAV AQIINNPTSA MNLLAANLPR SSNFFISYLI LQGFTIAGGA LFQVVTFFLF
YILGALLDKT LRKKWARFSG LGIVMWGTTF PIFTNLASIT LAFAIIAPMI LLFGCVAFLL
AFIAYGHNLT YCFVEAPDNR GLHYPRALFQ TFTGLYLGQV CLLGLFVVGK GWGCVALQAI
GIAFTAFCHI NLKEAFGRLT TVLPIDCMKP LDGFSKTVSY QGESDFKTKV LDKRKNEKAD
LLKEDQKDHE RVEEETQQLE GGQNLVPLLA DRDFKTTESK NWLVRFVRPD VFLNFRHAKR
MIPATYNMEE EVVDDKHAFD QPAIAAQMPK LWIPKDPYGW SQKEIESNRK IIEMTDENSG
FSENCKPQFF GESPV
//
