ID A0A2H0ZG52_CANAR Unreviewed; 664 AA.
AC A0A2H0ZG52;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Ubiquitin-protein ligase E3A N-terminal zinc-binding domain-containing protein {ECO:0000259|Pfam:PF16558};
GN ORFNames=B9J08_004649 {ECO:0000313|EMBL:PIS49625.1}, CA7LBN_004125
GN {ECO:0000313|EMBL:QWW25243.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS49625.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS49625.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS49625.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS49625.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS49625.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QWW25243.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA7LBN {ECO:0000313|EMBL:QWW25243.1};
RA Finianos M.;
RT "Candida auris outbreak in lebanese hospital.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UFD1 family.
CC {ECO:0000256|ARBA:ARBA00006043}.
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DR EMBL; PEKT02000009; PIS49625.1; -; Genomic_DNA.
DR EMBL; CP076753; QWW25243.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZG52; -.
DR STRING; 498019.A0A2H0ZG52; -.
DR EnsemblFungi; B9J08_004649-t37_1; B9J08_004649-t37_1-p1; B9J08_004649.
DR VEuPathDB; FungiDB:B9J08_004649; -.
DR VEuPathDB; FungiDB:CJI96_0004501; -.
DR VEuPathDB; FungiDB:CJI97_004803; -.
DR VEuPathDB; FungiDB:CJJ07_001438; -.
DR VEuPathDB; FungiDB:CJJ09_004662; -.
DR VEuPathDB; FungiDB:QG37_07382; -.
DR OMA; TRHQHEW; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR Proteomes; UP000825438; Chromosome V.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.10.330.10; -; 1.
DR Gene3D; 2.40.40.50; Ubiquitin fusion degradation protein UFD1, N-terminal domain; 1.
DR Gene3D; 6.10.130.10; Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL); 1.
DR InterPro; IPR032353; AZUL.
DR InterPro; IPR042556; AZUL_sf.
DR InterPro; IPR004854; Ufd1-like.
DR InterPro; IPR042299; Ufd1-like_Nn.
DR PANTHER; PTHR12555; UBIQUITIN FUSION DEGRADATON PROTEIN 1; 1.
DR PANTHER; PTHR12555:SF13; UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1; 1.
DR Pfam; PF16558; AZUL; 1.
DR Pfam; PF03152; UFD1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000230249};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 545..570
FT /note="Ubiquitin-protein ligase E3A N-terminal zinc-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF16558"
SQ SEQUENCE 664 AA; 75377 MW; B15602ADFAAE70C5 CRC64;
MIILSLQLSK ALPRHSDKCL LPPSLLQTTI DETPELPHPL VYHLNDGASS IAVGVKEFTA
EEGTVCVPQF IFEKLKGHTV TVSLADVPKA TFLQLKPAQF YPHITNWKYY LESQLSKNYT
TLTKHKLFVI DDPLAKTAVD IIVEDANAPT VVVVDTDTIL DVLPLNDIMA AQQLGQNDAI
SALENIPTFH ESGVLEVVPF NQSPVPKLFK IDLRKVKESF SLVLRSENIN EAYNVDLLVA
LDKFVKLDNF AFETMSQDSA ASHTDKRIDI NINSDLIVNH LEKFKEEDAC ELYAAVFAWD
HNAKVKLEMV PFTKGDKLVK ENGTSNETKC SNCGKSIEKS KLPLHEAFCS RNNVRCSCGS
TFFKEIPSSH WHCEKCDPLL AGESTLFKFK HDRLVHSGPY RCEDCDSTSE YSDFISLVKN
HKSTKCPSKL HECMFCHLIV SQEEETYEDR FTNLTHHENQ CGNKTTECFE CNRVFKRKDL
KSHMQMHYMD KVELNTETVR LCANENCVSI VNDDSNDLGL CDTCYGPLYA TVLDPTRIKL
QNRIERRYVL QLTKGCGNVW CQNPQCATAT SPRPMKEVIQ HVQSELLLLV VTPELPITRK
KGVKSDANKF YFCLTESLQK RKELVDRLVD DGQYSRDMVL RAVNRSRDED SAREWLLKNG
LPLR
//
