ID A0A2H0ZGK0_CANAR Unreviewed; 390 AA.
AC A0A2H0ZGK0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein {ECO:0000259|Pfam:PF01212};
GN ORFNames=B9J08_004774 {ECO:0000313|EMBL:PIS49747.1}, CA7LBN_004018
GN {ECO:0000313|EMBL:QWW25136.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS49747.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS49747.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS49747.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS49747.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS49747.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QWW25136.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA7LBN {ECO:0000313|EMBL:QWW25136.1};
RA Finianos M.;
RT "Candida auris outbreak in lebanese hospital.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the threonine aldolase family.
CC {ECO:0000256|ARBA:ARBA00006966}.
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DR EMBL; PEKT02000009; PIS49747.1; -; Genomic_DNA.
DR EMBL; CP076753; QWW25136.1; -; Genomic_DNA.
DR RefSeq; XP_018166463.1; XM_018315685.1.
DR AlphaFoldDB; A0A2H0ZGK0; -.
DR STRING; 498019.A0A2H0ZGK0; -.
DR EnsemblFungi; B9J08_004774-t37_1; B9J08_004774-t37_1-p1; B9J08_004774.
DR VEuPathDB; FungiDB:B9J08_004774; -.
DR VEuPathDB; FungiDB:CJI96_0004379; -.
DR VEuPathDB; FungiDB:CJI97_004678; -.
DR VEuPathDB; FungiDB:CJJ07_002741; -.
DR VEuPathDB; FungiDB:CJJ09_004786; -.
DR VEuPathDB; FungiDB:QG37_06853; -.
DR OMA; MRQTGFM; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR Proteomes; UP000825438; Chromosome V.
DR GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR CDD; cd06502; TA_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR023603; Low_specificity_L-TA-like.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; NF041359; GntG_guanitoxin; 1.
DR PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF017617; Thr_aldolase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000230249}.
FT DOMAIN 15..305
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
FT MOD_RES 218
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR017617-1"
SQ SEQUENCE 390 AA; 43319 MW; 1E2FB9DEFF039609 CRC64;
MTILEERETF SVHNEFRSDT FTLPTKHMNQ VVMDKISSGT LFLGDSVYKE DPSTLELEAR
MAQLTGKEAA LFCVSGTLSN QIGLRAALHQ PPYSILCDHR AHIYLHEAGG TATLSQAMVH
PVKPENGNYL TLEDILEEYT PDDGDIHAAP TKVISLENTL HGIVTPVDEI RRISEFARSQ
GIVMHLDGAR LINASVATGV SLQEYCQYFD SVSICLSKSL GAPIGSVLVG DRKFIEKANH
FKKQAGGGIR QAGLMTLMAL TALEDNWNKI ADAHAFAREV GEFCQQHSIA LESPVDTNFV
FIDLKKNKMN DALLVKIAEK HGVKLMGGRI AFHFQLSRES VENLKAALYE CKQESLRHPY
EGRRCNKQMY NVDVIKNLQQ LKVDSQTTST
//
