ID A0A2H0ZKT7_CANAR Unreviewed; 891 AA.
AC A0A2H0ZKT7;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Magnesium and cobalt transport protein CorA {ECO:0008006|Google:ProtNLM};
GN ORFNames=B9J08_002836 {ECO:0000313|EMBL:PIS51261.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS51261.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS51261.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS51261.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIS51261.1}.
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DR EMBL; PEKT02000007; PIS51261.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZKT7; -.
DR STRING; 498019.A0A2H0ZKT7; -.
DR EnsemblFungi; B9J08_002836-t37_1; B9J08_002836-t37_1-p1; B9J08_002836.
DR VEuPathDB; FungiDB:B9J08_002836; -.
DR VEuPathDB; FungiDB:CJI96_0000674; -.
DR VEuPathDB; FungiDB:CJI97_002891; -.
DR VEuPathDB; FungiDB:CJJ07_004614; -.
DR VEuPathDB; FungiDB:CJJ09_001261; -.
DR VEuPathDB; FungiDB:QG37_02324; -.
DR OMA; DVCFPDY; -.
DR OrthoDB; 1358357at2759; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd12829; Alr1p-like; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 3.
DR InterPro; IPR044089; Alr1-like.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR PANTHER; PTHR21535; MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8; 1.
DR PANTHER; PTHR21535:SF51; MANGANESE RESISTANCE PROTEIN MNR2; 1.
DR Pfam; PF01544; CorA; 2.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230249};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 829..852
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 101835 MW; D5AC442A9A2BD303 CRC64;
MAKKKSARQR KLRSKQQGRE KLREEHLVSQ PNSRPVSPTG NQAHRNSYMD HHPRTNSMSS
ARERRMSEYD QSPPFNKDFA PLTDRNLQTL LEQNNAQHSS HRFGSVALDM DKFAREQDVS
PYDAIDAFSN HSPNSGGSLE FGESNPPSEH SSDSTSLDDV CYLDYYDDEQ GRTGQMHKWP
DLEVLEEFIH EELEELQDEP SELNEVNFRY PVARRVSHTP EVADEDDAPL LNRVQVNEVD
TWGESSSFKA ARKPLKPWEA SQSNIHTILN NGKKKSDTLC RFTYFREDLD QTLHSPTLAG
LVADSEKADL SDENYIRNSL KELFDPHFQS IHHRSPRATT PGPDTHHDGI NGKDQQGKEP
HHSRQGSVPP NVSRSSAAAQ NLKGSTPQAA ASHSSLAHFS GGTTSVNSLS TSPHLHHDPF
WLDIQDPSEE EMKVIAKTFG LHPLTTEDIF MDEAREKVEM FNSYYFLCFT SFDIVYERRK
QKEKENEKKI NKLMEYNYQP SRFSWEWFQN KLGWKDDTVL RSNAKKSGSS SIKSKSKRIR
NGELCPLNMY MIVFKHGVLT FHFSATPHPI NVRRRARMLK DHLTVSPDWI CYALIDDITD
SFAPMIDSIE AEVYLIEDEI MRMHSGDRES ADESEDSDSE SIADLQDNRP RHSNDVFVRR
HRSKSVVETT EPSKLDFLRL KKRDSKGDYF SLKSRRSAIS KTTTTTSTDS SRIVAWKRKG
DMLRRIGECR KRVMSVMRLL STKADVIRGY SKRFSESDVV KPVEDNPLIS TRSATKHEIL
MYLGDIQDHI VTMVQSLNHY EKLLARSHSN YLAQINIDMT KVNNDTNDVL GKITVLGTIV
LPVNVVTGLW GMNCIVPGQD APGLTWFYGI LFGIFLFSIT SYLYAKKVYN L
//
