ID A0A2H0ZN41_CANAR Unreviewed; 1150 AA.
AC A0A2H0ZN41;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 15 {ECO:0000256|ARBA:ARBA00019613};
GN ORFNames=B9J08_003619 {ECO:0000313|EMBL:PIS52008.1}, CA7LBN_000421
GN {ECO:0000313|EMBL:QWW21675.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS52008.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS52008.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS52008.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS52008.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS52008.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QWW21675.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA7LBN {ECO:0000313|EMBL:QWW21675.1};
RA Finianos M.;
RT "Candida auris outbreak in lebanese hospital.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 15 family.
CC {ECO:0000256|ARBA:ARBA00009807}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PEKT02000007; PIS52008.1; -; Genomic_DNA.
DR EMBL; CP076749; QWW21675.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZN41; -.
DR STRING; 498019.A0A2H0ZN41; -.
DR EnsemblFungi; B9J08_003619-t37_1; B9J08_003619-t37_1-p1; B9J08_003619.
DR VEuPathDB; FungiDB:B9J08_003619; -.
DR VEuPathDB; FungiDB:CJI96_0002152; -.
DR VEuPathDB; FungiDB:CJI97_003692; -.
DR VEuPathDB; FungiDB:CJJ07_005301; -.
DR VEuPathDB; FungiDB:CJJ09_000486; -.
DR VEuPathDB; FungiDB:QG37_04834; -.
DR OMA; RYQKYYE; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR Proteomes; UP000825438; Chromosome I.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd12191; gal11_coact; 1.
DR Gene3D; 1.10.287.2920; -; 1.
DR Gene3D; 1.10.246.20; Coactivator CBP, KIX domain; 1.
DR InterPro; IPR033789; Gal11_coact.
DR InterPro; IPR036529; KIX_dom_sf.
DR InterPro; IPR036546; MED15_KIX.
DR InterPro; IPR008626; Mediator_Med15_fun.
DR Pfam; PF18535; Gal11_ABD1; 1.
DR Pfam; PF16987; KIX_2; 1.
DR Pfam; PF05397; Med15_fungi; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000230249}.
FT DOMAIN 10..85
FT /note="Mediator complex subunit 15 KIX"
FT /evidence="ECO:0000259|Pfam:PF16987"
FT DOMAIN 229..307
FT /note="Gal11 coactivator"
FT /evidence="ECO:0000259|Pfam:PF18535"
FT REGION 75..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1150 AA; 128504 MW; 570539A2E701D57F CRC64;
MNNIPAPMGG TWHSKQNPDE RQKIIQIVVA TLKDIQGVDF NEATAIKQAH DFEKYMFMKC
TSRDEYLNQI KQKVHQMRGS LRNNSGTGMQ QPQNPQNAQN VQNQQFSAHA RQAQAHQQQQ
QQQQQQQQHQ QQQIPGQQNI GLGLGTDAAN QGMNFFPQNQ MQMRNGMMPQ SSPQQGHQQV
PQAQMNRAAP QQQMPQQQQQ QQQHQQQQNS SSGPQQGSGP QGINRNIGNQ LTPQQIQQLS
AMIKNVPIPP VFLNKIPNLP PNVNTWARIY DLAQKKVIPS SSLPAIKEVH NAHLSIVMHQ
QSQRLAQRRM SNMNGGPGSG GAMASTSSND QNININSLNN TNTGMNNMNN MNNMDKLSRP
STGQMNMQNQ QMQQQQAAFK NNSNKNDQYT MSNSMGMQRP QSRQSQTTPM MKQQQMSNQS
NLNIAGPNPG NQQQQQTLGK MPNFQITPQD MMEYQAQALA YLSRAQQDGK IPPNLDNNAK
QNFIRKYIYH QKATAWRNEQ LKAAQSKGNG SAQLNVGPQR TPQQSLMGQG GFPSQPSQQQ
NQPQQQVMGG LQSMGQPQQS PMMGNMQQPN AASMMNQGNN QPLFSPVMQQ KFPMQGQQVN
LGNVNAPSNQ IRRPQGVPPI TDEMKMKLRS LFDEVARGDS FQSKNHTTSL SDQDKLRMKD
LMVKINQQYA NVDSVLSYYY VLTSDIGGTK KLIQMKFMSR NIIESYQKGI YLANPEILEK
LIVHFQRYFD VVKKELTARR QQQQQQQQQQ QPQKIDSTQP QMSAAQQRPA MNQPTAQMTG
QRPMQPLPQG DQRFMPQNAS QGAQNYMPSG MGQLPNMASQ SQAQQVPPVP PQQQSQPQQQ
LSNQRSMGVQ QPSQQQFTRN ATYGQISQNQ PDWSKAVNPE QRGAQPSPQM QSQPVPKNTA
KGKKASTSGT AGRRKSTKAS GTMPTPGNSA PTPATLANAI KTPNSMPTPQ VIQSNSNKGT
PIDVSPNSDN KGANVTSKEP IVGEVFGANK VDSKLDSRRE LSKTDPEQFF FAALSNLLEV
DKADSTNGTK GGSAGTDHTK SPLSPNSAEW TCAVKPEAIK SAFCQVDCIK ELTAMEILEE
CAKMVDRDAK KREEVNSRKR EREEPDDIDI LFNDTDAKKI KSEDFDRFMF EPVEFDEWKN
WLTGLQQAKV
//
