ID A0A2H0ZNC9_CANAR Unreviewed; 639 AA.
AC A0A2H0ZNC9;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 13-SEP-2023, entry version 24.
DE SubName: Full=Methylenetetrahydrofolate reductase {ECO:0000313|EMBL:PIS52131.1};
GN ORFNames=B9J08_003742 {ECO:0000313|EMBL:PIS52131.1}, CA7LBN_000313
GN {ECO:0000313|EMBL:QWW21567.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS52131.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS52131.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS52131.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS52131.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS52131.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QWW21567.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA7LBN {ECO:0000313|EMBL:QWW21567.1};
RA Finianos M.;
RT "Candida auris outbreak in lebanese hospital.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
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DR EMBL; PEKT02000007; PIS52131.1; -; Genomic_DNA.
DR EMBL; CP076749; QWW21567.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZNC9; -.
DR STRING; 498019.A0A2H0ZNC9; -.
DR EnsemblFungi; B9J08_003742-t37_1; B9J08_003742-t37_1-p1; B9J08_003742.
DR VEuPathDB; FungiDB:B9J08_003742; -.
DR VEuPathDB; FungiDB:CJI96_0002275; -.
DR VEuPathDB; FungiDB:CJI97_003816; -.
DR VEuPathDB; FungiDB:CJJ07_003680; -.
DR VEuPathDB; FungiDB:CJJ09_000364; -.
DR VEuPathDB; FungiDB:QG37_00940; -.
DR OMA; GVFKTIP; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR Proteomes; UP000825438; Chromosome I.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000230249}.
FT REGION 315..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 71808 MW; 4D61A156EFA5F99C CRC64;
MSTVTSKIRS LAPGERFCSF EFFPPKTDAG FRNLLARLSR MMALNPLFLT VTWGAGGSTA
EKSLDLAATC QKELGVTTVL HLTCTNTNKE IIEDALQRAR AAGIKNILAL RGDPPRTEEY
WTPNCDFSSA VDLVRYIRQN HGDYFCIGVA GYPEGHVEGA DASQQDPRKD LPYLVEKIEA
GADYVVTQLF FDVDKFVAYE KLLRETPQLK NVILIPGLMP ITTYRVFVRA TRLSHANVPR
DILSKLDAFA NDDDTVKTIG LDVLTKMISE IDQRTEGRIR GYHFYTLNLE KAVASIINRS
PVLQNMISHN KSVEHDDAVA SDSDEEFAPP MKNGRRKSSV NENQVAVPDD AKRALVSKAL
SKDPKSIVDI STGKGALGKD ATWDEFTNGR FGDSNSPAYG EIDGYGPNLK LHTNKEVEET
WGNPESTADI TRIFVDYLSN KINVLPWADS ELSPETGLIQ EELFELNERG WFTLASQPAV
NNCKSSDKIL GWGPPNGHIF QKSFVEFFIP KKQWKDELLP RISKQVEEKT ITYYCGDASG
HISSNLPIGK GKDSNTKSAV TWGVFPSKEV LQPTIIDYES FKAWNEEAFL LWLEWARCYR
KDSKSYQLLN DIYNNYYLVS LVHHDFTDEF VLWTTLLSD
//
