ID A0A2H0ZNY0_CANAR Unreviewed; 1887 AA.
AC A0A2H0ZNY0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DOCKER domain-containing protein {ECO:0000259|PROSITE:PS51651};
GN ORFNames=B9J08_003624 {ECO:0000313|EMBL:PIS52013.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS52013.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS52013.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS52013.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00984}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIS52013.1}.
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DR EMBL; PEKT02000007; PIS52013.1; -; Genomic_DNA.
DR STRING; 498019.A0A2H0ZNY0; -.
DR EnsemblFungi; B9J08_003624-t37_1; B9J08_003624-t37_1-p1; B9J08_003624.
DR VEuPathDB; FungiDB:B9J08_003624; -.
DR VEuPathDB; FungiDB:CJI96_0002157; -.
DR VEuPathDB; FungiDB:CJI97_003697; -.
DR VEuPathDB; FungiDB:CJJ07_002688; -.
DR VEuPathDB; FungiDB:CJJ09_000481; -.
DR VEuPathDB; FungiDB:QG37_04841; -.
DR OMA; KPIFFDP; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000230249}.
FT DOMAIN 1399..1808
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1812..1887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1829..1880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1887 AA; 213965 MW; AAE889B90EE4822E CRC64;
MSWIPTEEFL HGRIIKPFLP FDKHPTLKND NFRNLYPGDE VFVFETKQNK WARGYSLTRP
FPSDFTITSV NLDELPGLNR QIVVFPLKYM KVVEKVPLNM INAEDEFNNV HRSSNLAPTL
KETEQYVATA VSDPGVIASS NGSSNERKTQ PPPLPFETFT FANDLVEEIT YTLNLLTSHI
YAMYSIGEFR LFTKLTELYV ELDETRVKLT HGDLTRDEVQ ITEETASQLL STIPKSLASK
ASRLNDKSYD LEDKNTDVNG YKAILARDAF NGDLLSLKNS TPALMALYQQ YCALLPKFPI
NAHNKREEYL LDSLPNKKLT HGSPSHILVD FKSVSGSSQY QPPGFAGMIA YMYVRNTQRR
LTEAFAVHTD TVDELVFVEK ISAALFRNIP ASEVENHRVY LVAVLVEQLD LPQKEGGAVK
IERINKGVAA GVTDITRVFS RNSGSLASGE SHQFAINLFG SYVSNKSSSV DSSKIDNNGW
GELIDRIIKG SNHGVAVNPR AEKLVVSVKE FRHQLVGDSA ETESLDIRSN DASMKTAPIA
KIKPIFYDPL AENYERIYLK MGKVSMSYPT NKNDLLTFEV SAPNNDSISF AKASNQIEKP
KWQFVSVTTN EVIGEIVKVN GISLKGHGRK PPKQDSLHLS MYVNGVIAGE ADILYKSGNR
LVEFNKPESQ VIDVISVSSK KTIAQVDIHT TYIGKIFNSE IAIDNLLQNN RFFVGTQAGL
DDLTQTLLDF CKLDIASLVK FFAESLTRIF EIIHRSLTAT DGLNYSNVMA TAFKALVHLL
DTNFGKRDQY VFMFDTYLKE YKKDPAIGLF ILERMAEVFS QVETNWNAMS RSVCRVLVLL
TKLALDPVTE VKDKSPYLEK LSDLFTSASH FLKLQAAALI NDQILVMELV DFVMAFESQF
PDGKLLSIVI NFIDSISFRG VGVDDEDVVA KKTTAALKEH RFVITKLLVI YRLFSSKAPR
NIKQINLLVS RAVYWCMEIF MGPVDIHASR FACSILNCVC DLIYRNLDMT EVRKIALTLS
KFIFPMSRTL IRYNKFTRGH DYFKPKKAFT TLFPNSYPFK EIFLDAIVSE EVIVEVLVEL
TAIICYICQI KKKVSEDERT NQVLNLEDDS FFDSSKYMSS NGWNENILTV LHALSLMRQG
RFFPEDKWLS FSGIIAESSL SCLEMLKPFL LSTAIPHQEQ PELFDRSIWG TYLKSLLKLA
ALPPVSIEHL STIPRKACYS ITGEMRDKIA DIINEVWDAL AWNATDGDVV RFNLTKFGGY
QVEFINSEYG ILQDLMLFAL QRNQSCQIVS IKILWSILVS EHVLSNTIVD VEKECLTGLY
NIYTRNGYKP GLPEQNYFIE RMKATIRLDR EDVAYPYIVK FVSNIEGFLD VLNDLNSVPV
GIEFEDDRTF HKLNINAYLK QASRPELFHS FINQMYEENL KKKDYVQAAL SLELLASTYE
WDHYSIQPAS YRPKFPEQSS FERKEHLTKL IAHNYVKGNS LERAIDVYND LLDAYSEHTY
DLKSFAFVHN KLAKLYLDLE SSDKLSPSYF RVAYIGAGFP ANIRGKEQII EGQPFEHITS
VHERMLKRYP GARIITDDEQ AREIKEKNHT GRYLHINAVE PVYEISDKLF NTSIGVRQYV
KNKDLRFFSS LRRVGNAKSV FDLWTEEVTY ETTLSFPTLM NRSDIKSSSV VKLSPLDNAI
RSIMNKNDDL SQLESMINIA VKEKVDFKSL LSDLSRHLAG TVDSPVNGGV GQYRGFFTDS
RYAGKPEHAE NMRLLRNAFN DLTMVLSRCL HLHGVLILPS MKTSQNVLVE SFKLNFKDEI
AELKIDTNYD GRNYEFNSNT HTKDRQMPER PSSSSAYGAS LQRSVSRSSS AASSSTDPSL
QNSYSSSHAG SQTGQKRTAL NWRNVAR
//
