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Database: UniProt
Entry: A0A2H0ZPC7_CANAR
LinkDB: A0A2H0ZPC7_CANAR
Original site: A0A2H0ZPC7_CANAR 
ID   A0A2H0ZPC7_CANAR        Unreviewed;      1078 AA.
AC   A0A2H0ZPC7;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=B9J08_001960 {ECO:0000313|EMBL:PIS54816.1};
OS   Candida auris (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Metschnikowiaceae; Clavispora;
OC   Clavispora/Candida clade.
OX   NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS54816.1, ECO:0000313|Proteomes:UP000230249};
RN   [1] {ECO:0000313|EMBL:PIS54816.1, ECO:0000313|Proteomes:UP000230249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B8441 {ECO:0000313|EMBL:PIS54816.1,
RC   ECO:0000313|Proteomes:UP000230249};
RX   PubMed=27988485; DOI=10.1093/cid/ciw691;
RA   Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J.,
RA   Chowdhary A., Govender N.P., Colombo A.L., Calvo B., Cuomo C.A.,
RA   Desjardins C.A., Berkow E.L., Castanheira M., Magobo R.E., Jabeen K.,
RA   Asghar R.J., Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT   "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT   continents confirmed by whole-genome sequencing and epidemiological
RT   analyses.";
RL   Clin. Infect. Dis. 64:134-140(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PIS54816.1}.
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DR   EMBL; PEKT02000005; PIS54816.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000230249; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000230249};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230249};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      117    453       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      517    946       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      984   1056       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
SQ   SEQUENCE   1078 AA;  123338 MW;  1C337C6380A3A41A CRC64;
     MSQDPNALKR AWYTGHEGAH SLPVGSQTID SKLELSESQH QFLKRVKRPS GNEEPSEFEK
     ELYEMTESAS NFHEELQSWK RPPLRKDYDK KDISFQQLDA EEATNGEESS ARFFGITEEG
     NSILCNVTGF LHYFYVPVPR GFFPDQHLSQ FVAYMKANYF GIHDIEIVRK ESIWGFNNNT
     KSPFFKVIVN NSRNITKIRG AFERGEVRFE QLFPSTCVTY DNITYLLRMM IDCGITGMSW
     ITLPAGSYSI IDKDLKVSTC QIECTVDYRQ LISHPSEGEW LKMAPLRIMS FDIECAGRKG
     VFPEASQDPV IQIANVISRY GESRPFVRNV FTVKSCSPII GSEIFSNEKE EDMLMAWRDF
     VVRADPDVII GYNTANFDLP YLLDRAKALN LSKFPYFGRM VNIRQEAKDS VFSSRAYGTR
     ENKVVNIDGR MQLDLLQFIQ REYKLRSYTL NSVSAHFLGE QKEDVQHSII TDLQNGTAET
     RRRLAVYCLK DAYLPLRLLE KLMCLVNYTE MARVTGVPFS YLLARGQQIK VISQLFRKCL
     QEDIVVPNLK SEGGNEEYEG ATVIEPIRGY YDVPIATLDF SSLYPSIMMA HNLCYTTLLN
     KQSIKAFNLT EEDYTHTPNG DYFVKSTKRK GILPTILHEL LTARKKAKAD LKKEQDPFKR
     DVLNGRQLAL KISANSVYGF TGATVGKLPC LAISSSVTAF GREMIERTKN VVQEKYNTAN
     GYTYDAQVIY GDTDSVMVKF GHQDLETCMK LGEEAAAFVS THFINPIKLE FEKVYFPYLL
     INKKRYAGLY WTNPEKFDKM DTKGIETVRR DNCRLVQNVI TRVLEYILEE RNVPKAEKFV
     KQTIADLLQN RVDLSQLVIT KAFSKHEYDS KQAHVELAKR MRKRDAGSAP TLGDRVAYVI
     INSSSSKNYE KSEDPLYVLE NSLAIDVKYY LENQLSNPLL RIFEPILGEK KAKELLAGAH
     TRTIKMSAPK GGGLMKFAKK AELCKNCKAP LKSNNKGALC ENCISKAPEL YCDALAQMNY
     LENKFSRLWT ECQRCQGSLH QEVLCSNKDC PIFYMRKKAE KDVTQQAQEL QKWDETVW
//
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