ID A0A2H0ZRU8_CANAR Unreviewed; 625 AA.
AC A0A2H0ZRU8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=B9J08_002984 {ECO:0000313|EMBL:PIS51403.1}, CA7LBN_000957
GN {ECO:0000313|EMBL:QWW22211.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS51403.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS51403.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS51403.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS51403.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS51403.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QWW22211.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA7LBN {ECO:0000313|EMBL:QWW22211.1};
RA Finianos M.;
RT "Candida auris outbreak in lebanese hospital.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; PEKT02000007; PIS51403.1; -; Genomic_DNA.
DR EMBL; CP076749; QWW22211.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZRU8; -.
DR STRING; 498019.A0A2H0ZRU8; -.
DR EnsemblFungi; B9J08_002984-t37_1; B9J08_002984-t37_1-p1; B9J08_002984.
DR VEuPathDB; FungiDB:B9J08_002984; -.
DR VEuPathDB; FungiDB:CJI96_0000814; -.
DR VEuPathDB; FungiDB:CJI97_003055; -.
DR VEuPathDB; FungiDB:CJJ07_003638; -.
DR VEuPathDB; FungiDB:CJJ09_001121; -.
DR VEuPathDB; FungiDB:QG37_05108; -.
DR OMA; DIRGFMD; -.
DR OrthoDB; 2056550at2759; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR Proteomes; UP000825438; Chromosome I.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000230249};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 300..443
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 463..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 71211 MW; A8E198E777464852 CRC64;
MADKELTVFV VDLHPAAASS HDYLYEVLSG KLLKGLKTDY VSVVGYHSPL TKHELAEKKV
FPGVNVLSNF ETPSYEQLVR IRKELRVNDS WESSQSDSFQ SFIFSLSLLE DTKTKAFTRN
IVLLTSHESP LSSLTEQKAD GIPNILKNLR VNMIVVVDGL EESSETYSQW ALLKPSFAEF
IIMSSKQARY TAQNVPPAKK VRPLPIYRGE LRFGSDFFAV IEDRSYACEA DDLALSWPVE
VYPAAKKDVS SISFHDYILE DGRPIRLERK SSHYVWSKNE EYQRPEYPDE EDVDTKKFDK
VEVESKDFTP GFKFSNFDLI ALDDDLTESA RLKIFSAFDI LGFIKSESIP PAYLTSETFF
VVPEKAATLR ANLSHTILAK ALLETESAAL ARFVRKQAKE VELGVLIPIK IKDGTKNSFN
YLLVRLPFRE DENIGNFPSL KEHKSDKIVP KLMEQFIESK TFTEQETKDS QSLHNHRVTM
RTSQSSKLPL PNTSKEIFST SSTSQVRFLN YVRKIIIRSL DEDDLDKFLQ QKSLISNVLK
SDSFASNFFN LRNCLSYSAS SASFVDLSRR AKDTSRRLVD ELDIKYVRKE DLKKKKPRKG
GDTFDTKGYY GADEGEYDAV PDFGF
//
