ID A0A2H0ZYR9_CANAR Unreviewed; 790 AA.
AC A0A2H0ZYR9;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Vacuolar protein sorting-associated protein 70 {ECO:0008006|Google:ProtNLM};
GN ORFNames=B9J08_001532 {ECO:0000313|EMBL:PIS55433.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS55433.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS55433.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS55433.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIS55433.1}.
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DR EMBL; PEKT02000004; PIS55433.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H0ZYR9; -.
DR EnsemblFungi; B9J08_001532-t37_1; B9J08_001532-t37_1-p1; B9J08_001532.
DR VEuPathDB; FungiDB:B9J08_001532; -.
DR VEuPathDB; FungiDB:CJI96_0000001; -.
DR VEuPathDB; FungiDB:CJI97_002119; -.
DR VEuPathDB; FungiDB:CJJ07_004125; -.
DR VEuPathDB; FungiDB:CJJ09_001960; -.
DR VEuPathDB; FungiDB:QG37_03388; -.
DR OMA; NVVIASW; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000230249}.
FT DOMAIN 156..228
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 345..534
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 671..783
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 259..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 89605 MW; 0695B82A8424A48C CRC64;
MEKQPFDLNT RPSLLHRVAR LTVAALVFIF LVSKLNWLEE AENTKDPKEV VLQSLETNHA
RNWSRIYTAE KHLAGTNYGL VEFTRCKFAE YGAKATVDDY HVLLSYPEDH SLSLMDKHGN
VEFKASLRED EVKEDPTSVG NDTVPTFLGY AANGNVTAQY VYVNYGTIDD FSWMEENGVS
VKGRIVIARY GRINRGLKVK FAQDFGAEGI LIYSDPADDG DITTANGYKP YPYGPARQES
SVQRGSVMFL GALDATPGDP TTPGYASKKG AKREDPHNSI CKIPALPVSY KEVKPLLAKL
NGHGKNVPES WKGTLEGVDY STGPHPSATL NLYNKQEYKI TPIWNVYGEF EGKNKDEAIV
IGNHRDAWIK GGAGDPNSGS SVLIEIARAL GDLKQSGFEF ERTIILKSWD GEEYGLIGST
EFGEYAAKRL QKNVVAYINT DVAVQGSLLS LGASPVLNKV LRKVAKWLPY PGKDNVSLYD
HFVKEKDDII RNLGSGSDYT VFLEHLGIPS ADISFKSGKK DPIYHYHSNY DSFHWMDEFG
DPGFVFHNLA AKYLALLALE LSQHKVIEFS LHDYAKDLLF YFKLAKETIP KDWLDRKISP
HLMAEYIARD HKNDAAIDRA SQNLYAENSD VVFPEFLLPF QCRHMRRMMK EHEHHKTVTL
GEIVNHTQQQ LEQLKEKTSS FDYASAKLQS RYNDRRDLHW WQRVKLHFRI KHQNKLIQYF
ERNFLHEEGL HRRPWFKHIV FAVGRYAGYA GQTWPGIREA VEDEDFSGTV KWLGIAARAA
RRVSLGLHVA
//
