ID A0A2H1A5N7_CANAR Unreviewed; 1242 AA.
AC A0A2H1A5N7;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=B9J08_000691 {ECO:0000313|EMBL:PIS58201.1}, CA7LBN_002268
GN {ECO:0000313|EMBL:QWW23467.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS58201.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS58201.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS58201.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS58201.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS58201.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QWW23467.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA7LBN {ECO:0000313|EMBL:QWW23467.1};
RA Finianos M.;
RT "Candida auris outbreak in lebanese hospital.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; PEKT02000002; PIS58201.1; -; Genomic_DNA.
DR EMBL; CP076750; QWW23467.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H1A5N7; -.
DR STRING; 498019.A0A2H1A5N7; -.
DR EnsemblFungi; B9J08_000691-t37_1; B9J08_000691-t37_1-p1; B9J08_000691.
DR VEuPathDB; FungiDB:B9J08_000691; -.
DR VEuPathDB; FungiDB:CJI96_0003407; -.
DR VEuPathDB; FungiDB:CJI97_000692; -.
DR VEuPathDB; FungiDB:CJJ07_004305; -.
DR VEuPathDB; FungiDB:CJJ09_002652; -.
DR VEuPathDB; FungiDB:QG37_01526; -.
DR OMA; LCTALNW; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR Proteomes; UP000825438; Chromosome II.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR GO; GO:0006796; P:phosphate-containing compound metabolic process; IEA:UniProt.
DR CDD; cd14483; SPX_PHO81_NUC-2_like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF03105; SPX; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS51704; GP_PDE; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000230249};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..173
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REPEAT 461..487
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 534..566
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 568..600
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 890..1239
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
FT REGION 639..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1242 AA; 139266 MW; 0091629BFB68A4F6 CRC64;
MKFGKYLASR QLELPEYSGY FIDYKALKKL IKQLGGGVDV STTEPNSQFQ IQQKLKDNKA
SFFFRVEREL DKVNSFYLEK QANMAINLDL LVMKKEELLT KSSDMASDPS VNASSLNFKN
SILFLNLYQN FKKIHQDLLR LQQFIELNEA GFSKVVKKWD KRSKSHTKEL FLQTAVSVQP
VFHKNEINEL SDLVIQSLFD LESIMDGDYS VLENYRGRRS VSAPSNYSEI LARHSSISGI
DQQDMSDQDK STFPGSYPNT RHSSFTGFQP SQIDDLYSSF VNVATLKDTD ESVLNRWIEK
VKSSSKGSQN EAASKYLFSK IFLLAISNLK ISDAFLKTFL ELIDYQIDFE VSSEDFNSNK
SIIHECVSLQ PASTSEEHQH VSINNGVKVI TSVDNIDHSR VFVIDFIINN LSQDALSGLL
IRKDMNGRTC LHYASQNNCL ELLTLILPHF PKDHLDDLDN DSMSALLLAI KHNNFDIIKL
LVQHGSNRYP VTNESKLQYL PVNYACKFGD YKTVEYLLRY ADTSPEMINQ PDVEGLFPLH
VIARSGNYSL IKLLTEFGAS VNQLDGLNKW PPLFYAASEG NIKTTEELIK FGAKLDIVDE
DGYNVLYYCV IEGHIGVLNH ILSYRKEISK SERASSADVT MDSIAESSLP RQSKNKESSG
SILDEEEDSE DSGDIEKNVD SIPHLELPPP ILPLRRYGHN FLEQKVLIEL IFSNEKGSIN
LFNSGTGLQP GRITITSNIS DIVPRNILLP NNGGEKETTS CIFQTEVDSL SEFRVDFEIF
PKFGTRLIAK TTALNLRQLD TSSLEVNSTS LPLFDLRLRN IGELKFNYQV IFPFAGTLLE
TTKYDTYWKS STNFVKNKPT NKLNGQGLSP NNFLSPSNIS NSTGEAKNGN GGVGNQVTSA
TAPGAKSNSS FVTATSLSGD YLRIKVCLLN DGSPFVCPHW SISVADNVEL LLPNLTAEQL
TSIASSLFDY EKIIADLSKM TVKDIVLIKK LLRIIYLPLD TFLNILNPEI RCSIELVFPS
LYELDRIPFS GNIQVNLNKF IDLTLNSVFN HIRALKVKSK NGASRSLIFL SSNSIVCKIL
NWKQPNFPVF LIMNGIIFNN ATGLFEAHSA NGLPMEELGC TKDNDKHDCK GVDLLHKQGS
KEGQLNANDQ ELTVRSIKDA VNFTIDNNLI GVITSIHLLD LVPKLIPLIR SRGLVLVASN
DIMDPENNPD TLSKELDIYS RTEINGLRFD DVLSFKDEPG TM
//
