ID A0A2H1A691_CANAR Unreviewed; 966 AA.
AC A0A2H1A691;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA ligase 4 {ECO:0000256|ARBA:ARBA00022073};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=DNA ligase IV {ECO:0000256|ARBA:ARBA00031942};
DE AltName: Full=Polydeoxyribonucleotide synthase [ATP] 4 {ECO:0000256|ARBA:ARBA00030676};
GN ORFNames=B9J08_000904 {ECO:0000313|EMBL:PIS58406.1}, CA7LBN_002448
GN {ECO:0000313|EMBL:QWW23647.1};
OS Candida auris (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowiaceae incertae sedis;
OC Candida/Metschnikowiaceae.
OX NCBI_TaxID=498019 {ECO:0000313|EMBL:PIS58406.1, ECO:0000313|Proteomes:UP000230249};
RN [1] {ECO:0000313|EMBL:PIS58406.1, ECO:0000313|Proteomes:UP000230249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS58406.1,
RC ECO:0000313|Proteomes:UP000230249};
RX PubMed=27988485; DOI=.1093/cid/ciw691;
RA Lockhart S.R., Etienne K.A., Vallabhaneni S., Farooqi J., Chowdhary A.,
RA Govender N.P., Colombo A.L., Calvo B., Cuomo C.A., Desjardins C.A.,
RA Berkow E.L., Castanheira M., Magobo R.E., Jabeen K., Asghar R.J.,
RA Meis J.F., Jackson B., Chiller T., Litvintseva A.P.;
RT "Simultaneous emergence of multidrug-resistant Candida auris on 3
RT continents confirmed by whole-genome sequencing and epidemiological
RT analyses.";
RL Clin. Infect. Dis. 64:134-140(2017).
RN [2] {ECO:0000313|EMBL:PIS58406.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B8441 {ECO:0000313|EMBL:PIS58406.1};
RA Munoz J.F., Gade L.G., Chow N.A., Litvintseva A.P., Loparev V.N.,
RA Cuomo C.A.;
RT "Candida auris genome assembly and annotation.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QWW23647.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA7LBN {ECO:0000313|EMBL:QWW23647.1};
RA Finianos M.;
RT "Candida auris outbreak in lebanese hospital.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572, ECO:0000256|RuleBase:RU004196}.
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DR EMBL; PEKT02000002; PIS58406.1; -; Genomic_DNA.
DR EMBL; CP076750; QWW23647.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H1A691; -.
DR STRING; 498019.A0A2H1A691; -.
DR EnsemblFungi; B9J08_000904-t37_1; B9J08_000904-t37_1-p1; B9J08_000904.
DR VEuPathDB; FungiDB:B9J08_000904; -.
DR VEuPathDB; FungiDB:CJI96_0003195; -.
DR VEuPathDB; FungiDB:CJI97_000922; -.
DR VEuPathDB; FungiDB:CJJ07_003867; -.
DR VEuPathDB; FungiDB:CJJ09_002863; -.
DR VEuPathDB; FungiDB:QG37_02858; -.
DR OMA; EGIMIKH; -.
DR Proteomes; UP000230249; Unassembled WGS sequence.
DR Proteomes; UP000825438; Chromosome II.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd07903; Adenylation_DNA_ligase_IV; 1.
DR CDD; cd07968; OBF_DNA_ligase_IV; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR044125; Adenylation_DNA_ligase_IV.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR000977; DNA_ligase_ATP-dep.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR029710; LIG4.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR00574; dnl1; 1.
DR PANTHER; PTHR45997; DNA LIGASE 4; 1.
DR PANTHER; PTHR45997:SF1; DNA LIGASE 4; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000230249};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 406..534
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT DOMAIN 686..785
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 858..963
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
SQ SEQUENCE 966 AA; 111330 MW; 4F7384AD62EBADDF CRC64;
MSVDTSFLDN VKEPKNFNNN APFDLLVSDL FLKLESTTSE NKAPFDTVSA KKTHIIEEFV
KTWRTHFGPN ILPAVRLIFP NRDGRKYHVK DVALTRLVNK LLKLQPGSGD YQIIKNWKKS
YQQKANLAND SERRQLGDLP LIIARIISRR RDQTVPVKSS VTVAEVNDVL DQLAQKTQSK
EQLALLEPFV EKLTIPEVRY VFQMILKESM LSFFERAFFL AWHPDAYNLF KVCEDMKKIF
WVLSDPEKRL LPTQLCVQPM YMFVPQSSQK LDISYDSLCK RMTVALQTEN KDKKLVDLYK
QEQIEGHFLI EEKIDGDRML MHMVNGKFRW HTRRRRDYTL VYGENIHIGS LTKHLTDALD
DKVHSIVLDG EMVAWSKDRE MILPFGTLRS AAIQEALKQF DVIDVYEGNN SWPLFLIFDI
LHLNGRDLTG LPLFYRKSLI NKVVKEVPHR FEILEWVKAK SPTDIKANMQ RIVSERNEGI
MVKSLLSKYR VYSRESTWIK VKPEYLENFG ENLDLVVIGK IGRVKTSYIC GLKDIEAEGC
YKSFCMVANG FSNAVYRQIE SKLVNFWHDY TVEKPPATLI QFGTKKPDYW INPANSIVLE
IKARSIEVTA ETPYAAGSTL HNLWCRAVRE DKDYDECITL QEYQELKARY STDIYKNQDV
NRNRKRPGEN SIIEKYEKVK KLKIAAESDL LTGIHFVIAT DYKDPDESKS MSAEALKQLV
RSHGGAIELN PKRNELHEKT VMVVGTNLTP RLQRWYKEGF DVISPRWIVE SIRHEKLLPI
EPSFIVASVN AGFMNLAHQN VDEFGDSYVV TATSSQGLLQ HLMSLTVKKR LADDSIERCR
RLFLEESDRE SDPHWWMLFY GLKFHIVGSR SSITSHKAAA GSLSQRIARF GGECIGDVHQ
SHYIVVPEKV EKKHEVVAEV ARVSRELGAR YVEGKKIARV VRESFVVESV KEGVVVDAED
HNYSAD
//
