ID A0A2H1EEC6_9ARCH Unreviewed; 287 AA.
AC A0A2H1EEC6;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989};
DE EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989};
GN Name=gmd {ECO:0000313|EMBL:SHO42851.1};
GN ORFNames=NSIN_10201 {ECO:0000313|EMBL:SHO42851.1};
OS Candidatus Nitrosotalea sinensis.
OC Archaea; Nitrososphaerota; Nitrosotalea.
OX NCBI_TaxID=1499975 {ECO:0000313|EMBL:SHO42851.1, ECO:0000313|Proteomes:UP000232412};
RN [1] {ECO:0000313|Proteomes:UP000232412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Herbold C.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. GDP-mannose 4,6-dehydratase subfamily.
CC {ECO:0000256|ARBA:ARBA00009263}.
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DR EMBL; FRFC01000001; SHO42851.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H1EEC6; -.
DR Proteomes; UP000232412; Unassembled WGS sequence.
DR GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR CDD; cd05260; GDP_MD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 2.
DR InterPro; IPR006368; GDP_Man_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:SHO42851.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000232412}.
FT DOMAIN 4..257
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 287 AA; 33315 MW; 4ECBDDA3AE3F70EE CRC64;
MIPVEMTDVE SLSHAVRNSD PHEVYHLAAQ SYVSVSFDQP LYTYDTTGLG VIRILDEMRK
FNPKIKFYHA SSSEMYGIEK SKIKNEKTSF HPVSPYAIAR VLGYWTVNMY RNRYDMYATN
GILFNHESPI RGVEFVTRKI SNGVAKISLG LEKTLKLGNL SAKRDWGYAP EYVEGMWKML
QQKKSDDYIL ATNRVHSIKD FVNEACKVAG ISISKIESSK ENFRPFDVQY MRGDYTKARK
KIGWKPKTSL KNIVKIMVEE DISRWNRWLK GEQFPWDVTP DRRSVKI
//
