ID A0A2H1EHH0_9ARCH Unreviewed; 451 AA.
AC A0A2H1EHH0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN Name=trpE {ECO:0000313|EMBL:SHO46457.1};
GN ORFNames=NSIN_30118 {ECO:0000313|EMBL:SHO46457.1};
OS Candidatus Nitrosotalea sinensis.
OC Archaea; Nitrososphaerota; Nitrosotalea.
OX NCBI_TaxID=1499975 {ECO:0000313|EMBL:SHO46457.1, ECO:0000313|Proteomes:UP000232412};
RN [1] {ECO:0000313|Proteomes:UP000232412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Herbold C.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate + L-glutamine = anthranilate + H(+) + L-glutamate +
CC pyruvate; Xref=Rhea:RHEA:21732, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16567, ChEBI:CHEBI:29748, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359; EC=4.1.3.27;
CC Evidence={ECO:0000256|ARBA:ARBA00000329};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 1/5. {ECO:0000256|ARBA:ARBA00004873}.
CC -!- SIMILARITY: Belongs to the anthranilate synthase component I family.
CC {ECO:0000256|ARBA:ARBA00009562}.
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DR EMBL; FRFC01000004; SHO46457.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H1EHH0; -.
DR OrthoDB; 25514at2157; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000232412; Unassembled WGS sequence.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF9; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022822};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00022822};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:SHO46457.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000232412};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 23..152
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 185..438
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT COILED 274..301
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 451 AA; 50942 MW; 1FBC913467C6DB9C CRC64;
MATFGHSSLK IIPLDYTGSQ FDLYNSISRQ FQHSFFFESL TGPEEMAETS LIGFDPSVII
KGYHDRVVLH YKRGSSITIP TSNPLAEVKK LVQNTPDQKY RYVGGAVGII NYDAIRLWEK
IPQAHKISDE PLMEFGIYTD GIIYDNKEKR TFYFYYDENR INNVSSSSID CGKFTISNIT
ENLDEERFAS MVQKAKKYIH DGDIFQVVLS RKVNFKSDGD HLRVYKILRQ INPSPYMYHM
KLGKRTIIGS SPEMLLRITG TQVETFPIAG TRPITNDEKK NQELKEEMLH DEKELAEHTM
LVDLGRNDIG RVCKYGSVHV KELMAVKKFS HVQHIVTHVV GTLDKKYDMY DAIKAVFPAG
TVSGAPKIRA MEIIDELEPD ARGEYAGAIG YFSFNGCCDF AIAIRSIFMN GSEGFVQSGA
GIVTDSVAHN EWMETSHKAN AMITALKEAS K
//
