ID A0A2H1FG34_9ARCH Unreviewed; 159 AA.
AC A0A2H1FG34;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Phosphopantetheine adenylyltransferase {ECO:0000256|HAMAP-Rule:MF_00647};
DE EC=2.7.7.3 {ECO:0000256|HAMAP-Rule:MF_00647};
DE AltName: Full=Dephospho-CoA pyrophosphorylase {ECO:0000256|HAMAP-Rule:MF_00647};
DE AltName: Full=Pantetheine-phosphate adenylyltransferase {ECO:0000256|HAMAP-Rule:MF_00647};
DE Short=PPAT {ECO:0000256|HAMAP-Rule:MF_00647};
GN Name=coaD {ECO:0000256|HAMAP-Rule:MF_00647};
GN ORFNames=NCS_11530 {ECO:0000313|EMBL:SMH71718.1};
OS Candidatus Nitrosotalea okcheonensis.
OC Archaea; Nitrososphaerota; Nitrosotalea.
OX NCBI_TaxID=1903276 {ECO:0000313|EMBL:SMH71718.1, ECO:0000313|Proteomes:UP000230607};
RN [1] {ECO:0000313|Proteomes:UP000230607}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Herbold C.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Reversibly transfers an adenylyl group from ATP to 4'-
CC phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
CC {ECO:0000256|HAMAP-Rule:MF_00647}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA +
CC diphosphate; Xref=Rhea:RHEA:19801, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57328,
CC ChEBI:CHEBI:61723; EC=2.7.7.3; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00647};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC {ECO:0000256|HAMAP-Rule:MF_00647}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00647}.
CC -!- SIMILARITY: Belongs to the eukaryotic CoaD family. {ECO:0000256|HAMAP-
CC Rule:MF_00647}.
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DR EMBL; LT841358; SMH71718.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H1FG34; -.
DR UniPathway; UPA00241; -.
DR Proteomes; UP000230607; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_00647; PPAT_arch; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR023540; PPAT_arch.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR43793; FAD SYNTHASE; 1.
DR PANTHER; PTHR43793:SF1; FAD SYNTHASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00647};
KW Coenzyme A biosynthesis {ECO:0000256|HAMAP-Rule:MF_00647};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00647};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00647};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00647};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00647}.
FT DOMAIN 13..148
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 159 AA; 17667 MW; ABD4A1E162543D37 CRC64;
MQDGMTRFKL VALGGTFDII HRGHIELLRN GFSISSKVII GLTSDELARK KGKIPINDYP
RRYKTLEDVI KKNFPNSKYV ISKLDNDFGP AVLEQEVEAL IVSEETSSKG KDLNKLRTER
NSPPVVVIVV PMALAKDGTR ISTTRIKNSE IDADGNILS
//
