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Database: UniProt
Entry: A0A2H3BMZ3_9AGAR
LinkDB: A0A2H3BMZ3_9AGAR
Original site: A0A2H3BMZ3_9AGAR 
ID   A0A2H3BMZ3_9AGAR        Unreviewed;      1082 AA.
AC   A0A2H3BMZ3;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   05-JUN-2019, entry version 9.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=ARMSODRAFT_932680 {ECO:0000313|EMBL:PBK72271.1};
OS   Armillaria solidipes.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Physalacriaceae;
OC   Armillaria.
OX   NCBI_TaxID=1076256 {ECO:0000313|EMBL:PBK72271.1, ECO:0000313|Proteomes:UP000218334};
RN   [1] {ECO:0000313|EMBL:PBK72271.1, ECO:0000313|Proteomes:UP000218334}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=28-4 {ECO:0000313|EMBL:PBK72271.1,
RC   ECO:0000313|Proteomes:UP000218334};
RG   DOE Joint Genome Institute;
RA   Sipos G., Prasanna A.N., Walter M.C., O'Connor E., Balint B.,
RA   Krizsan K., Kiss B., Hess J., Varga T., Slot J., Riley R., Boka B.,
RA   Rigling D., Barry K., Lee J., Mihaltcheva S., LaButti K., Lipzen A.,
RA   Waldron R., Moloney N.M., Sperisen C., Kredics L., Vagvolgyi C.,
RA   Patrignani A., Fitzpatrick D., Nagy I., Doyle S., Anderson J.,
RA   Grigoriev I.V., Guldener U., Munsterkotter M., Nagy L.G.;
RT   "Lineage-specific genetic innovations streamline the genomes of
RT   Armillaria species to pathogenesis.";
RL   Nat. Ecol. Evol. 0:0-0(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KZ293422; PBK72271.1; -; Genomic_DNA.
DR   EnsemblFungi; PBK72271; PBK72271; ARMSODRAFT_932680.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000218334; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005657; C:replication fork; IEA:EnsemblFungi.
DR   GO; GO:0008296; F:3'-5'-exodeoxyribonuclease activity; IEA:EnsemblFungi.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0043137; P:DNA replication, removal of RNA primer; IEA:EnsemblFungi.
DR   GO; GO:0045005; P:DNA-dependent DNA replication maintenance of fidelity; IEA:EnsemblFungi.
DR   GO; GO:0006278; P:RNA-dependent DNA biosynthetic process; IEA:EnsemblFungi.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000218334};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218334};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      110    452       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      516    947       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      984   1060       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     45       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2H3BMZ3}.
FT   COILED     1060   1080       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1082 AA;  121929 MW;  166B7F92AE2C9BAB CRC64;
     MAPLSAIKEN VPLVRPRVDS GEQGPASKKR KLASSALYNS QPTQSSFTEV LERIKEEAGD
     TSNAEGGADY WARPALPSIN EKKDKLVFQQ IDIDETNHGG SISLRMFGVT EAGHSVLAYV
     TDFLPYFYVG QPRGFVEDDI DDFASYLNTQ VGYDVVIRVE IVKKRSLWGY RGDDRVPFLK
     ITINEPRNLP KVRGLFEKNG VDFNGLFVRK DGDGIATFES NIAYTLRFMI DTKVVGMNWI
     EVPGGRYKIV SEEGKKSHCQ LEISMRWDAF TSHTPEGNWS KVAPLRILSF DIECAGRKGI
     FPEASIDPVI QIANMVTRQG ESKPFIRNIF TLNSCSPIVG SQVLAHKDES KLLLAWRKFV
     EQVDPDVVIG YNIGGFDFPY LLDRAKALQL KKFPFLGRMK YNETKTVNTH FSSKAYGQRD
     SKDTPLDGRL QLDVLQFMQR EHKLRSYTLN SVCAQFLGEQ KEDVHHSVIT ELQNGTPESR
     RRLAVYCLKD AYLPQRLLDK LMCFVNYIEM SRVTGVPFNY LLARGQSIKV LSQLFRKANE
     EGYLVPNLKG EGTDDQYEGA TVIEPKKGYY DAPIATLDFS SLYPSIMMAH NLCYTTLLDK
     GTVERLQLVE DVDYIRTPNH DLFVKSSRRK GLLPTVLEDL ISARKRAKAD LKKETDPFKR
     AVLDGRQLAL KISANSVYGF TGATIGKLPC LAISSSVTSY GRQMIEKTKS EVEAQYSVAN
     GHSHDAEVIY GDTDSVMVKF GPTDLAKVME LGAEAAEFVT AKFIKPIKLE FEKVYFPYLL
     ISKKRYAGLY WTRPEKYDKM DSKGIETVRR DNCRLVSTVI ETCLHKMLID RDVRGAEEYV
     KQTISDLLQN KVDMSQLVIT KALAKSDYAG KQAHVELAER MKQRDAGSAP ALGDRVAYVI
     VKGIKGAAAY EKSEDPLYVL DNSIPVDTRY YLENQLSKPL MRIFEPILGE KANSLLSGDH
     TRTIQIATPT VGGLMKFAVK SVTCLGCKTQ LRKSNSKTNG AVCNNCRPRI GELYQKQVSA
     SSELQIRFSR LWTQCQRCQG SLHQQDVLCT SKDCPIFYMR KKAQKDVEDS NSVLERFESE
     SW
//
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