ID A0A2H3BQC0_9AGAR Unreviewed; 1062 AA.
AC A0A2H3BQC0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Antiviral helicase {ECO:0000313|EMBL:PBK71840.1};
GN ORFNames=ARMSODRAFT_954631 {ECO:0000313|EMBL:PBK71840.1};
OS Armillaria solidipes.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Physalacriaceae; Armillaria.
OX NCBI_TaxID=1076256 {ECO:0000313|EMBL:PBK71840.1, ECO:0000313|Proteomes:UP000218334};
RN [1] {ECO:0000313|Proteomes:UP000218334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28-4 {ECO:0000313|Proteomes:UP000218334};
RX PubMed=29085064; DOI=10.1038/s41559-017-0347-8;
RA Sipos G., Prasanna A.N., Walter M.C., O'Connor E., Balint B., Krizsan K.,
RA Kiss B., Hess J., Varga T., Slot J., Riley R., Boka B., Rigling D.,
RA Barry K., Lee J., Mihaltcheva S., LaButti K., Lipzen A., Waldron R.,
RA Moloney N.M., Sperisen C., Kredics L., Vagvoelgyi C., Patrignani A.,
RA Fitzpatrick D., Nagy I., Doyle S., Anderson J.B., Grigoriev I.V.,
RA Gueldener U., Muensterkoetter M., Nagy L.G.;
RT "Genome expansion and lineage-specific genetic innovations in the forest
RT pathogenic fungi Armillaria.";
RL Nat. Ecol. Evol. 1:1931-1941(2017).
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ293423; PBK71840.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3BQC0; -.
DR STRING; 1076256.A0A2H3BQC0; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000218334; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:PBK71840.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000218334}.
FT DOMAIN 144..300
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 378..582
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1062 AA; 120052 MW; 67BC001075F7BAC5 CRC64;
MADLFSFLDN VPDEPMDEPV IESSAMPVDT PESSARKRKA EVSQNRGPDM NGADEEPAGK
KPRLDAPNPI VLDDFETEAK REVAASAGLQ GSVEAGRLEL RHQVRHQVAV PPGYNYTPIT
KHVPPAKPDR EYKFELDPFQ KVSVYAIQRN ESVLVSAHTS AGKTVVAEYA IAQCLNRKQR
VIYTSPIKAL SNQKYREMLA EFGDVGLMTG DVTINPTATC LVMTTEILRS MLYRGSEIMR
EVAWVVFDEI HYMRDKERGV VWEETIILLP HTVRYVFLSA TIPNAMQFAE WICKSHDQPC
HVVYTDFRPT PLQHYLFPAG GEGIYLVLNE KGEFKEDNFS KAMGQLQANA GEDPADPRGG
KGKKGKTKKG GEKKGPSDIA RIVKKIMQGN YYPVIVFSFS KRDCEAHALS LTKYEFNSQD
EQDLVNNIFT NAIDNLSEDD KQLPQIVTFL PLLRRGIGIH HSGLLPILKE VIEILFQEGL
IKVLFATETF SIGLNMPAKT VVFTGTRKFD GREQRSISSG EYIQMSGRAG RRGLDDRGVV
ILMCDEKLEP ATAKEMIKGE ADRLDSAFHV GYNMVMNLMK VEGISPEYML ERCFFQFQSS
AGIPQLENEL RKEEEAHKTF VIEDEELVAQ YYEFRQQLDQ MKGDFREVIT HPTYVLPFLK
AGRLVKVKYK TLDFGWGVFI NFEKRLPPKN RPMPKADDVP PQEQYVLDVL LNCAAGSSVS
KDRSNIAATP GGVLPCPPHQ KGQPLVVPVL LSTIEGISHL RLYLPKDLRS SESRDTLWKS
VGEVHRRFPD GVPLLDPVQN MGIKDDKFLG LVKKIEAMEN QMFKSPLHDD KRLPELYTLY
SKKRDVQDRI RGLKKRIQST HDVLQLEELK CRKRVLRRLG FTTAEDIVDV KGRVACEIST
GDELLLTELI FNGVFNTLEP EQCAALLSCF VFDEKSEQQT KLKEELAAPL RIMQEIARRI
AKVSKESKLP VDEDAYVSSF KVELMDVVIQ WCRGASFSEI CKLTDTFEGS LIRVFRRLGE
LLRQMAQAAK VIGNAELQKK FEKSSEMLER PNSVIFCSSL YL
//
