ID A0A2H3BVT8_9AGAR Unreviewed; 845 AA.
AC A0A2H3BVT8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:PBK74979.1};
GN ORFNames=ARMSODRAFT_1080637 {ECO:0000313|EMBL:PBK74979.1};
OS Armillaria solidipes.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Physalacriaceae; Armillaria.
OX NCBI_TaxID=1076256 {ECO:0000313|EMBL:PBK74979.1, ECO:0000313|Proteomes:UP000218334};
RN [1] {ECO:0000313|Proteomes:UP000218334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28-4 {ECO:0000313|Proteomes:UP000218334};
RX PubMed=29085064; DOI=10.1038/s41559-017-0347-8;
RA Sipos G., Prasanna A.N., Walter M.C., O'Connor E., Balint B., Krizsan K.,
RA Kiss B., Hess J., Varga T., Slot J., Riley R., Boka B., Rigling D.,
RA Barry K., Lee J., Mihaltcheva S., LaButti K., Lipzen A., Waldron R.,
RA Moloney N.M., Sperisen C., Kredics L., Vagvoelgyi C., Patrignani A.,
RA Fitzpatrick D., Nagy I., Doyle S., Anderson J.B., Grigoriev I.V.,
RA Gueldener U., Muensterkoetter M., Nagy L.G.;
RT "Genome expansion and lineage-specific genetic innovations in the forest
RT pathogenic fungi Armillaria.";
RL Nat. Ecol. Evol. 1:1931-1941(2017).
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DR EMBL; KZ293418; PBK74979.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3BVT8; -.
DR STRING; 1076256.A0A2H3BVT8; -.
DR OrthoDB; 1584469at2759; -.
DR Proteomes; UP000218334; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000218334}.
FT DOMAIN 374..506
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 558..799
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 845 AA; 95740 MW; 570119E3C72C2407 CRC64;
MASPQISKPK KLKKISDRKI HIPTAGPVAS LPSPPDSSLF SKEPASPTPS SSAPPPLITN
VPKCLRRYPS IIHIIAKLRE VSETTQSASD FEAYAVIFCT SLSSNVLCSL ERTPHLDTND
PKYCATYYNV VDSAEYFRSW ACKKVEGEGE VGISMRLATS MLWFNATLKA LKELHKIVAH
MVANAKPLPG LPVGLPREDS VAKVPDVDES GSLESHRLRP PKLRISPLSV IVEEVLNDDA
PSSPASPNDT TVSRSTSSLG HLPTVDEPSS STDTLVSTPP DKAGFPARRK KLAQQIRRVY
KLAKERGHRL VRTEASTSTL TSEPTSESFK SFDRPQVVQI TYAIRQSALY HFEDPMNRVD
MPMPEDYAAM QVDEKGQLTS ATLQALILQI TSREVTQEGV LDTFFTGFRY FTTPAILARG
LLDRLEGMDD HEYDFTEQQH IVWAASKDLT EQRVVYVICL WLERYWNPTF DNEALEIFQE
YFLRHPECRP GSEMLELYRC LRKVGSGGAS RSKWLEHRSR QIARGFLYPR PKDTDFRFSS
VPDKTVPSRL RWFMTDAGVQ EFARQLTIQS SRLFRKIDPE GAVRSWIASE VEGRETRADV
VNWGRSLTFW ATISILQQPS VDGRVLFIGF WLDVAMTCLK HYDFNSAFAI YNGVVASPVN
RLRRTALASD RLSAREKGYH WIFEKVFDNF KEYRRIVQAV ALESRPMVPI LDPLVHDVSQ
VKTSLSKAMT EGRINFFPIR TICATIQTME QARLPYLFKR SAACQEWLTL KLQWAVNTKA
KLDVDDIDQY QMSRALEPRD PELEKIHSNP AMLWNLVATY NGYESVDSLT KFDLDAIFNI
RTCRT
//
