ID A0A2H3C607_9AGAR Unreviewed; 1966 AA.
AC A0A2H3C607;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=ARMSODRAFT_947436 {ECO:0000313|EMBL:PBK78509.1};
OS Armillaria solidipes.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Physalacriaceae; Armillaria.
OX NCBI_TaxID=1076256 {ECO:0000313|EMBL:PBK78509.1, ECO:0000313|Proteomes:UP000218334};
RN [1] {ECO:0000313|Proteomes:UP000218334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28-4 {ECO:0000313|Proteomes:UP000218334};
RX PubMed=29085064; DOI=10.1038/s41559-017-0347-8;
RA Sipos G., Prasanna A.N., Walter M.C., O'Connor E., Balint B., Krizsan K.,
RA Kiss B., Hess J., Varga T., Slot J., Riley R., Boka B., Rigling D.,
RA Barry K., Lee J., Mihaltcheva S., LaButti K., Lipzen A., Waldron R.,
RA Moloney N.M., Sperisen C., Kredics L., Vagvoelgyi C., Patrignani A.,
RA Fitzpatrick D., Nagy I., Doyle S., Anderson J.B., Grigoriev I.V.,
RA Gueldener U., Muensterkoetter M., Nagy L.G.;
RT "Genome expansion and lineage-specific genetic innovations in the forest
RT pathogenic fungi Armillaria.";
RL Nat. Ecol. Evol. 1:1931-1941(2017).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; KZ293415; PBK78509.1; -; Genomic_DNA.
DR STRING; 1076256.A0A2H3C607; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000218334; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000218334};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1397..1583
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1684..1949
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1966 AA; 220176 MW; D881815A39EF916E CRC64;
MDCIELNIHQ RILSDIASSV SETDDDYRYA GTLIASKVQT RIAERKTDYV PNGYSQPNGK
VDEEGTDRVF MPASRVHCNI AFGELVFNFP ESHISERIGT IMPVLIDVLR DVPYIDFDHC
LSWEDWSLPD QLVFSTVSAL LRVSGLHPQY SDSATGAIVA FISDIQTKIP TTAPLDILTQ
LAPALHGLYR AISSTSFAWS TSQWQQLREA LGGLCSVDNI DRLNRLIGDI VNEDVVDVDT
QHFIETFLAR YVSRGRPLSG YFIVCCVLET SWTVLAQVQA PPQTGPIGNS TEAVAANKAW
NSLMKRAAIE LDVAEEATVA TLKSTIQYAM QCFNDLLIQI EDMDTDPPPD TYAWETMSES
LKLASVCSVA LHELDEELYS RLLLLLSEES PIFDNLVQEA ALKATTVLVQ NFPEIAARMA
AHLRRFVTAP LSIFEFEFAS ETRAPPPLAA AAKCLAQCIK LAPGDDLIMS NMYSLLNYIA
ATSKEIYESS SNSQIFNNPL YSGQDQGTLH SVETGLHGLS EDEKRLVGIS TISVVTRLAL
EFRMEEVTRL TISMLLQRLR SAEPTMEAAI AYNLVDLALS APESAFVDII HVFSTINRSA
NPDDPRFSNN MVLAAQTRLA QELHRRPELY DVYLVELLTL FADKGVAIQN VKIANHHIKT
DDMIEQLASL LLPIDALLSH GDFNPHVDAS PAVVALFRNM WFLCILFHFT TDDAVDSNAM
AWQKPAMARI AIKTPATVVE ESQDAVASDV EYNSVIRQEY AHTVILKHKT SLTRHIPLRT
SDIRSLSSGQ IVFLLTMHDM ETMRSAAGLT SSLVTYFVND SLNRHLGLSS CMDAIAEKVI
RGCINDLNAQ AAQQALPEAL SSELRALLLC STHPVARARD IAFKFLNRLI SSFPSLMCDP
PLVFAILEVL TLLRRSCENE FTDEYNPVYE YTSTRAGITL ELTDSYQVRN EILAQLHRNA
NNWFELALGR APVELQSTLQ KYLAVHQSTS GTDGAELGAS VAEQFGKAIG PVQRQLISLS
ALSNRTLDKA NMLASQIASK GYFAGEAAGI RLASRAGADR LEKLPPQSAP SGEILALKEK
LAHTMEEIRG KTSTLTVQDL KRLLFRCTAM IISLSNCDYE LLHYLVALPF EVATPAAIST
GIEVWTWVIA EKNDIEVALM SEVLSAWSYT IRQEKGIFST SLNYGDPFYQ PVSYSPTEKG
EIDRGMLNAR RLLMPHALVL QMLFSRLQAA RYRRPGVMFL IQHLVLLSAR AYKTLSTHAL
AREARFSFLL FGFETLKSSH LDSFCESEMR ENLYSAAYSW FAVRPQWTYG ANRVQIDADV
KVLSEFLSYL QTDSVRASAV ISSLSPAQTP SRSTYYTNRL RTINQPLKFL VESEIYRLHV
WANPANDPRR GTDHIISSER ILLDAAWVQI LRTAWKIDPA IAVYMTERFK LPILRSEVGR
LVKSSTIEVL DIPEALPFLV EDRVDPAVRR DLRYLLLWAP VPPVIANTFF ERRYNSDPMV
LQYAHRVLEQ HPVELTFFFV PQVVQALRYD DLGYVARFIF ETAKISQLFC HQIIWNMKAN
CFKDDAGELE DPLKPILDSM TNLVVESLSG EARKFYDREF GFFHEVTSIS GKLKPFIKKT
KPEKKAKIDE EMAKIVVAIG VYLPSNPDGK VVDIDKKSGR PLQSHAKAPF MATFKVRKER
VTVDTDPDSL LDGEGGGIEV RTEYDVWQQA IFKVGDDCRQ DVLALQIIAM FKNIFTSVGL
TLYLYPYRVT ATAPGCGVID VVPNATSRDE MGRAKVNDLL DFFVAKYGGQ DTIAFQKARM
NFIQSMAAYS VACYILQIKD RHNGNIMIDG EGHIVHIDFG FLFDIGPGGV KFEPHSFKLN
HEMIVLMGGR YSQGYQLFQH LTVKAFLAIR PHAEQLISTV QLMLDTGFPS FKGEGTIKRL
RDRFALTLNE RQAAEHMMAV VRNAHENVRS TVYDEFQRLQ NGIPYK
//