ID A0A2H3C8L5_9AGAR Unreviewed; 703 AA.
AC A0A2H3C8L5;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=DRMBL-domain-containing protein {ECO:0000313|EMBL:PBK72483.1};
GN ORFNames=ARMSODRAFT_760804 {ECO:0000313|EMBL:PBK72483.1};
OS Armillaria solidipes.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Physalacriaceae; Armillaria.
OX NCBI_TaxID=1076256 {ECO:0000313|EMBL:PBK72483.1, ECO:0000313|Proteomes:UP000218334};
RN [1] {ECO:0000313|Proteomes:UP000218334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28-4 {ECO:0000313|Proteomes:UP000218334};
RX PubMed=29085064; DOI=10.1038/s41559-017-0347-8;
RA Sipos G., Prasanna A.N., Walter M.C., O'Connor E., Balint B., Krizsan K.,
RA Kiss B., Hess J., Varga T., Slot J., Riley R., Boka B., Rigling D.,
RA Barry K., Lee J., Mihaltcheva S., LaButti K., Lipzen A., Waldron R.,
RA Moloney N.M., Sperisen C., Kredics L., Vagvoelgyi C., Patrignani A.,
RA Fitzpatrick D., Nagy I., Doyle S., Anderson J.B., Grigoriev I.V.,
RA Gueldener U., Muensterkoetter M., Nagy L.G.;
RT "Genome expansion and lineage-specific genetic innovations in the forest
RT pathogenic fungi Armillaria.";
RL Nat. Ecol. Evol. 1:1931-1941(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
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DR EMBL; KZ293422; PBK72483.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3C8L5; -.
DR STRING; 1076256.A0A2H3C8L5; -.
DR OrthoDB; 23465at2759; -.
DR Proteomes; UP000218334; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000218334}.
FT DOMAIN 299..465
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
FT DOMAIN 541..667
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 703 AA; 77948 MW; 838326319A066E20 CRC64;
MSKKSKVSPK ASSTLHDYFS RPRTSKGTAA TPKAKVRPSQ GAKQKRKFVP PPSEDIIVIS
DDDDDAEGTP RQASFKKRRR TLSNSPGEVE IVAVHLAERD EKAKVEAEVQ LSFGKPTELL
LSSSPPIILE HEDRLAEEVL AFGRPTTLLL SPEAGPSAGV DTNEVLDVDE WGTGDDEREF
MDDDEVEILE DVTEQSVAPV NFGDASVRRA SENSVTTDIH SHVQTCLNAK PTRPPQTNGS
NAFAVLMSSH KEKEAWKEAS AMEDRTFRPN NSNGARRNAP FYKVLQGMPI AVDAFKYGAI
PGVTAYFLTH AHSDHYTNLS SSWTNGPIYC SEGTANLIMH MLKVPKNWVH ALPMDKPTVI
PNTGGVQVTL IEANHCPGSS LFFFEGKQTV NAGDSTFKSA FVGSSRVFRY LHCGDFRASP
RHVLHPAVKG KRIDHVYLDT TYLDPKYTFP PQPLVISACA ELAKRIAGGS VVKDKDARMD
VWLNAAPSKA KGKQKSDRIL MVVGTYSIGK ERIVKAMAQA LRTKVYCDAR KTAILRCQCD
PELHSLLTSN PLDALVHLVP LGVITSDRLK EYVERFKGHF SRAVGFRPTG WTYTPPAGID
LMPSVSTIIA RSQKNTFTHA DLAPARNSTS ALQLYMVPYS EHSSFSELTC FAMSFQWTKM
IATVNIGSEN SRQKMAKWVQ KWEAERKKKG NDYVVEYRQP DYW
//
