ID A0A2H3E4L0_ARMGA Unreviewed; 398 AA.
AC A0A2H3E4L0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Tethering factor for nuclear proteasome STS1 {ECO:0000256|RuleBase:RU368013};
GN ORFNames=ARMGADRAFT_1160483 {ECO:0000313|EMBL:PBL01261.1};
OS Armillaria gallica (Bulbous honey fungus) (Armillaria bulbosa).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Physalacriaceae; Armillaria.
OX NCBI_TaxID=47427 {ECO:0000313|EMBL:PBL01261.1, ECO:0000313|Proteomes:UP000217790};
RN [1] {ECO:0000313|Proteomes:UP000217790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ar21-2 {ECO:0000313|Proteomes:UP000217790};
RX PubMed=29085064; DOI=10.1038/s41559-017-0347-8;
RA Sipos G., Prasanna A.N., Walter M.C., O'Connor E., Balint B., Krizsan K.,
RA Kiss B., Hess J., Varga T., Slot J., Riley R., Boka B., Rigling D.,
RA Barry K., Lee J., Mihaltcheva S., LaButti K., Lipzen A., Waldron R.,
RA Moloney N.M., Sperisen C., Kredics L., Vagvoelgyi C., Patrignani A.,
RA Fitzpatrick D., Nagy I., Doyle S., Anderson J.B., Grigoriev I.V.,
RA Gueldener U., Muensterkoetter M., Nagy L.G.;
RT "Genome expansion and lineage-specific genetic innovations in the forest
RT pathogenic fungi Armillaria.";
RL Nat. Ecol. Evol. 1:1931-1941(2017).
CC -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC turnover of proteasome substrates. Targets proteasomes to the nucleus
CC and facilitates the degradation of nuclear proteins.
CC {ECO:0000256|RuleBase:RU368013}.
CC -!- SUBUNIT: Binds the proteasome. {ECO:0000256|RuleBase:RU368013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368013}.
CC Nucleus {ECO:0000256|RuleBase:RU368013}.
CC -!- SIMILARITY: Belongs to the cut8/STS1 family.
CC {ECO:0000256|ARBA:ARBA00006199, ECO:0000256|RuleBase:RU368013}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ293646; PBL01261.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3E4L0; -.
DR STRING; 47427.A0A2H3E4L0; -.
DR InParanoid; A0A2H3E4L0; -.
DR OMA; KDAYPYS; -.
DR OrthoDB; 1704120at2759; -.
DR Proteomes; UP000217790; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:UniProtKB-UniRule.
DR GO; GO:0031144; P:proteasome localization; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.1590; Tethering factor for nuclear proteasome Cut8/Sts1; 1.
DR InterPro; IPR013868; Cut8/Sts1_fam.
DR InterPro; IPR038422; Cut8/Sts1_sf.
DR PANTHER; PTHR28032; FI02826P; 1.
DR PANTHER; PTHR28032:SF1; FI02826P; 1.
DR Pfam; PF08559; Cut8; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU368013};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368013};
KW Protein transport {ECO:0000256|RuleBase:RU368013};
KW Reference proteome {ECO:0000313|Proteomes:UP000217790};
KW Transport {ECO:0000256|RuleBase:RU368013}.
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 42895 MW; 818B1786E823C6D6 CRC64;
MANVLQSPIG FQPRPVNHAP SPFGFGFGLS SPSSAMFSPG WQQAAPTANQ FSPFQSHNSN
HPQPVPLRTA KRRHEPEEAS DESMDQSPGP ERRIKRAPPK RARVVPAEAP KDEKDAKENK
APGQEDNDVD LGVLLASLPP QSLLPLLNSL IKAQPTLKSI ILPLIPRPTV QVALNALSDS
AKKLKDAYPY SNGSSFGAGS SNNKVSVFGG SGATFGKSVF GHSQHGQGPT SFVPSSGGGG
GMRDDYIVSR LRPHITEFAA ACMSYLPYFS YAAESSNATT LRALHKDKSQ PAETFLFLSA
LTSHLLSQPP LALASLVPLL LDRLIKEWNA WVDRVDAVVN REGGMFGSET VSTWARSLDD
FAGSKDERCA AAMRSVRDTW VAKVGWLVGR TMQHAMET
//
