ID A0A2H3EA95_ARMGA Unreviewed; 1896 AA.
AC A0A2H3EA95;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Microfilament motor {ECO:0008006|Google:ProtNLM};
GN ORFNames=ARMGADRAFT_1042871 {ECO:0000313|EMBL:PBL00633.1};
OS Armillaria gallica (Bulbous honey fungus) (Armillaria bulbosa).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Physalacriaceae; Armillaria.
OX NCBI_TaxID=47427 {ECO:0000313|EMBL:PBL00633.1, ECO:0000313|Proteomes:UP000217790};
RN [1] {ECO:0000313|Proteomes:UP000217790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ar21-2 {ECO:0000313|Proteomes:UP000217790};
RX PubMed=29085064; DOI=10.1038/s41559-017-0347-8;
RA Sipos G., Prasanna A.N., Walter M.C., O'Connor E., Balint B., Krizsan K.,
RA Kiss B., Hess J., Varga T., Slot J., Riley R., Boka B., Rigling D.,
RA Barry K., Lee J., Mihaltcheva S., LaButti K., Lipzen A., Waldron R.,
RA Moloney N.M., Sperisen C., Kredics L., Vagvoelgyi C., Patrignani A.,
RA Fitzpatrick D., Nagy I., Doyle S., Anderson J.B., Grigoriev I.V.,
RA Gueldener U., Muensterkoetter M., Nagy L.G.;
RT "Genome expansion and lineage-specific genetic innovations in the forest
RT pathogenic fungi Armillaria.";
RL Nat. Ecol. Evol. 1:1931-1941(2017).
CC -!- FUNCTION: Type-I myosin implicated in the organization of the actin
CC cytoskeleton. Required for proper actin cytoskeleton polarization. At
CC the cell cortex, assembles in patch-like structures together with
CC proteins from the actin-polymerizing machinery and promotes actin
CC assembly. Functions as actin nucleation-promoting factor (NPF) for the
CC Arp2/3 complex. {ECO:0000256|ARBA:ARBA00025586}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, actin patch
CC {ECO:0000256|ARBA:ARBA00004134}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KZ293646; PBL00633.1; -; Genomic_DNA.
DR STRING; 47427.A0A2H3EA95; -.
DR InParanoid; A0A2H3EA95; -.
DR OMA; ACGYKPC; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000217790; Unassembled WGS sequence.
DR GO; GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR CDD; cd01378; MYSc_Myo1; 1.
DR CDD; cd11858; SH3_Myosin-I_fungi; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035535; Fungal_myosin-I_SH3.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR024660; UCS_central_dom.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF837; MYOSIN-3-RELATED; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF11701; UNC45-central; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000217790};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 652..1331
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1389..1578
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT DOMAIN 1679..1737
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 304..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1226
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1567..1681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1737..1878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1656..1681
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1738..1759
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1794..1819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1829..1861
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 745..752
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1896 AA; 207326 MW; F19075C2441BB3FF CRC64;
MTSQDKDALG SLDTMLKKTA SSTSTDPLLP DELTYLISAF LPSRPTDDRS KAFLVLSAFC
QDKGQQMEAA AESLAKVFFP LMLPHLEETV EKDLLIGISF LTSLFQVDWQ SASFIFQQDG
VLELIMDSVD LNPSAELSLH VAHLLSQACG YKPCRTIFPP QTTKWLEFMS GPSQSTPVRA
AATIALIKLS RGSASDNADV ARENNTHIHK KDDELAAAMK NMVISGGDHS SIPDSVEGLA
YLSIDPVVKE ILSQDSDFLK ALLASVPRRR RDYTAETQSS LVYGVVLIIS NLCAYRPHLT
EEQSQMEKLR RMGKANSQSS GDSPLNDDEK VKGRIRKLMA NGVLDVFPAA LAGSDSQGVR
LGIGKALLSI VTDKENRGHV LRAGGAKVLL KIIKFSVSLA TSTSQTAALD PAYLESIQAL
SKLAITASPV QVFGPNDGAI YDIIRPFSLA LQHSSSLLLQ KFEILMALTN LSSHSAEVAS
RIADSEGLLN RVELLLLEDH VLIRRASMEL ICNLIAGSEK VFERYGGSAS GNSGVKSKVQ
VLLALSDVED IPTRLAASGA LATVTTELGA CQALLDLQRE RHRAVPILAQ LIDPSTDPEA
VDSAENHPGL LHRGVAPSKK AGKKVTPAPK KGGGTGKVAK ADWKEGFKKK QVGVSDMTLL
TTISNESINE NLQKRWTNAE IYTYIGAVLI SVNPFRDLGI YSEDTLQKYK GKNRLEVPPH
VFGIAESAYY NMNAYHENQC VIISGESGAG KTEAAKRIMQ YIAAVSGGQD SSIQEIKDMV
LATNPLLESF GCAKTLRNNN SSRHGKYLEI MFNAHGEPIG AQITNYLLEK GRVVGQVENE
RNFHIFYQFT KAATDEQREA FGLQGPEAYA YTSLSNCLEV QDINDAHDYS ETIKAMDIIG
LDANEQNEIF RMLAIILWLG NVQFEEKDDG NSQIADTSVT DFVAYLMDVD ASSVVKVLTS
KIVETQRGGR RGSVYDVPLN PAQASSGRDA LAKAIYNNLF EWIVSRVNVS MKPRSATSQV
IGILDIFGFE IFEDNSFEQL CINYVNEKLQ QIFIELTLKT EQEEYVREQI KWTPIKYFNN
KIVCDLIEER RPPGIFAALN DACATAHADP AAADNSFVQR TSMLSSNPHF EARGSQFLVR
HYAGDVMYNV SGMTDKNKDS LVKDLLDLVA SSTNQFLQTL FPDRPDPNSK KRPPTAGDRI
KASAGALVDN LMKAKPSYIR TIKPNQNRSS SEYDIKAILH QIKYLGLQEN IRVRRAGFAY
RNTFEKMVER FYLLSPNTSY AGEYTWQGDS KSGCEQILKD TGIAKDEWQM GVTKAFIKNP
ETLFALETMR DKYWHNMAAR IQRAFRNYMR YKHECARRIQ RFWKNNKEAL VYAQVRDYGH
QILGGRKERR RFSLLSYRRF MGDYLGINGK NDLGLEVAAP CNIGNDEVTF SGRIHLLVSK
FLQSSKPSPR FIVVTQKAVH IVIVQKKEGQ TQQMLERKIP LVTIKSIAMS NLRDDWMCLN
VNASEEGDPV FSCYFKTELA ANLMQLTHGS ITLNIGPTID YAKKKEKRAQ ITVARDETIK
KDDVYKSHTI RVPSGEPAGS LSRPPAKRKA GVVRPITQGK LLKAGGPSKP SGNRPKPTVR
ALPGKVASPV SVATSTPTPK PKPKPAPSSV TSSNGSRPPP APPRNVAPPP PPPPPPAAPA
VPMYRAKFAF DGQEGEMSLK KDDLVELVEK DDNGWWLVKK DGVEGWAPYN YLEIEAPKAA
PAPPPPPRAR APPSAPAAKQ APVPATKASL HSVTANASAK PVPVFPGMAA SNGSATPWKK
QVSTSSSTPD DSPGNSRPSS ALAGRAPPPL AAKPKPPVVA AKPAPKIPGK PPIPTASRPN
VGAPPPVRSG GISQAPGGQL DLAAALAKRA QRMNED
//
