ID A0A2H3EAF8_ARMGA Unreviewed; 1487 AA.
AC A0A2H3EAF8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=P-loop containing nucleoside triphosphate hydrolase protein {ECO:0000313|EMBL:PBL04406.1};
GN ORFNames=ARMGADRAFT_979821 {ECO:0000313|EMBL:PBL04406.1};
OS Armillaria gallica (Bulbous honey fungus) (Armillaria bulbosa).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Physalacriaceae; Armillaria.
OX NCBI_TaxID=47427 {ECO:0000313|EMBL:PBL04406.1, ECO:0000313|Proteomes:UP000217790};
RN [1] {ECO:0000313|Proteomes:UP000217790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ar21-2 {ECO:0000313|Proteomes:UP000217790};
RX PubMed=29085064; DOI=10.1038/s41559-017-0347-8;
RA Sipos G., Prasanna A.N., Walter M.C., O'Connor E., Balint B., Krizsan K.,
RA Kiss B., Hess J., Varga T., Slot J., Riley R., Boka B., Rigling D.,
RA Barry K., Lee J., Mihaltcheva S., LaButti K., Lipzen A., Waldron R.,
RA Moloney N.M., Sperisen C., Kredics L., Vagvoelgyi C., Patrignani A.,
RA Fitzpatrick D., Nagy I., Doyle S., Anderson J.B., Grigoriev I.V.,
RA Gueldener U., Muensterkoetter M., Nagy L.G.;
RT "Genome expansion and lineage-specific genetic innovations in the forest
RT pathogenic fungi Armillaria.";
RL Nat. Ecol. Evol. 1:1931-1941(2017).
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR EMBL; KZ293644; PBL04406.1; -; Genomic_DNA.
DR STRING; 47427.A0A2H3EAF8; -.
DR InParanoid; A0A2H3EAF8; -.
DR OMA; CCVNLIR; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000217790; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18034; DEXHc_dicer; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:PBL04406.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000217790};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT DOMAIN 22..206
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 381..557
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 579..693
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 979..1145
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1194..1379
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT COILED 372..399
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1487 AA; 170888 MW; CB54809FC10FD5F6 CRC64;
MMSAVDVVQD TTVHTRGYQQ EMLDESLKRN IIIAMDTGSG KTHIAVLRLK IEVEREPRKI
SWFLVPTVAL SEQQCRVIRA ALPVSVGLIS GSLEPNQWKD ASLWRKVIET HRIVVSTPQV
LLDALRHSYI QMGRDIGLMI FDEAHHTIDK APYNMIMKEF YFGLLPRDTP NLDSRYARPM
ILGLTASPIY GGDVAKAFSK IEGNLDSVIR TPRRNREELA KHVHRPVFKH VRYDPPDDAP
FSTNLESLRQ VVGTLNIDKD PYIISLRRNL DRVSPRSPEH YRLDQKLSKA ILKENTFTHK
GLHDFERTAL DILFDLGTWA ADWYVSTVLE QAKKACQGAE MPSWQTREKK YMLSLLNQVC
VCPVSYYAYD IVEDSSKKVA ELVKALLQEK EEFEAANEAF SGLVFVTRRD AVLALTEILT
HHPETKDKFK IGSLLGTSDS SYRHWFLDLT RKLLKQSQEE TLSDFRIGEK NLIISTSVAE
EGIDVQACGC VIRWDPPQNM VSWLQSRGRA RRKRSTFIVM FQRGGGDEDD VLKWESTEAE
VLRLCNEPER VMTAEPDEWD EWEEFRVPST GALLTLESAL PHLAHFVAVH PSASFNLDFQ
PMYDLDPPDL PLGWHSFENR STSVVVPYSG PWGSTVTLPR FLSSELRVHS TERIHPTKLS
AHRHAAFKAY KALYDNELLD DHLLPLFFRD EEIKKLESEV EKRVGIVSVS PQINPWAPVD
DSITVWYCSE LTLGDLPPLH MFTRTQCPPS WFENDGPPTL FTPHGPIKVT LRSIRQVGLD
EEVVTRAREY TRRLFWSMHG QRMTWDDLDF SYLFLPPHGT EDDEWEERRT WLREENEREG
RTNKFAFDAN AQDLGEAFWY PQDLTIVRAG FQFGKVYRFI AWRYDTVNEE ELEDMKTRYF
RHDDLEDIPC PLIVAEVLPS KSNFLVPPTK PAKEGSRQPP KRVLLIPNYT AATLISPLET
EYVSLLPSVL RALAMSLTVQ SMRDRMFTPS SHLYAIPSQL MTIAMTAPLS QERYNYQRLE
TLGDTVVKYL VSIQLLSEHP LWHEGYLSRR KDHAVANVRL ANENISREMF KWIIRDRLLS
KKWKPAYMHS TTPIREKKLA EVVATVPTKN EAKAKKAKKT AGELSTKVLA DVVESTIGAA
YLHGGFELGY ECAKFFRLEL NWQPTADRVS SLIQRVSRIE PEVRQRAELP EKTISQVESM
LGYEFRHKLI LLEALTHPSH QQDFGTVSYE RMEFLGDAVM DMVVSDYLYR AEGKEYSPGH
MHLRKSAVVN GHILAYLCLK CCLKVRSYMP RPMGSRNQIQ LEEEEEDIYL WKCLLHGSPR
VLEDQRVTFD RFQKLSDAIA DGLENRKIYP WAALTRLQAP KFFSDMIESL FGAVFLDSEG
SLERTRDVMR RTGVLPLLER IVKDDVDVLH PVSRLSVWAS KRGQKVKYRF TEEKGHISCV
IALKQEKGGE IKVLEDARVT DLNRGKVTKL EVKFAAAEKA IHLFHVE
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