ID A0A2H3FW53_FUSOX Unreviewed; 1686 AA.
AC A0A2H3FW53;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=indoleamine 2,3-dioxygenase {ECO:0000256|ARBA:ARBA00034333};
DE EC=1.13.11.52 {ECO:0000256|ARBA:ARBA00034333};
GN ORFNames=AU210_014919 {ECO:0000313|EMBL:PCD23397.1};
OS Fusarium oxysporum f. sp. radicis-cucumerinum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=327505 {ECO:0000313|EMBL:PCD23397.1, ECO:0000313|Proteomes:UP000219602};
RN [1] {ECO:0000313|EMBL:PCD23397.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD23397.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=27387256; DOI=10.1111/1462-2920.13445;
RA van Dam P., Fokkens L., Schmidt S.M., Linmans J.H., Kistler H.C., Ma L.J.,
RA Rep M.;
RT "Effector profiles distinguish formae speciales of Fusarium oxysporum.";
RL Environ. Microbiol. 18:4087-4102(2016).
RN [2] {ECO:0000313|EMBL:PCD23397.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD23397.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=28831051; DOI=10.1038/s41598-017-07995-y;
RA van Dam P., Fokkens L., Ayukawa Y., van der Gragt M., Ter Horst A.,
RA Brankovics B., Houterman P.M., Arie T., Rep M.;
RT "A mobile pathogenicity chromosome in Fusarium oxysporum for infection of
RT multiple cucurbit species.";
RL Sci. Rep. 7:9042-9042(2017).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the indoleamine 2,3-dioxygenase family.
CC {ECO:0000256|ARBA:ARBA00007119}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCD23397.1}.
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DR EMBL; MABQ02000011; PCD23397.1; -; Genomic_DNA.
DR STRING; 327505.A0A2H3FW53; -.
DR OrthoDB; 2723058at2759; -.
DR Proteomes; UP000219602; Chromosome 13.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:InterPro.
DR Gene3D; 1.20.58.480; -; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR000898; Indolamine_dOase.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR InterPro; IPR037217; Trp/Indoleamine_2_3_dOase-like.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF01231; IDO; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00371; FPNCR.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF140959; Indolic compounds 2,3-dioxygenase-like; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000219602}.
FT DOMAIN 984..1065
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1456..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1554..1597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1637..1659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1558..1597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1637..1651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1686 AA; 185947 MW; 528B9EAF07EF261D CRC64;
MSISSCPVSG SAGGECPVSG SSRSAQTRRG CAFSAATQPG DLHAAFDIPR GIDTEEWLRA
RERKTINELL YADYPSREEV DSVKSQQELD AMNASDHDLL AIALGAPARQ VLQRAQEIGP
QTGWRDGYLS VEHGFCPPDY EEPIAALARS PGRIWSDLCE RMPGCCARGR VREAVAALPL
VEGTEENIPD EALWGAVVAL GMLCSIYRFE DKHDGKDGLA ITDGATTKPQ CPMGDDLCEE
LEGIPLCIAL PYYQVSRRMG RTLPHLSFPD QASYNLKIRD VKSNTPYLAR FDNTDLRWPM
FGERAEVAFL KGCADTSASF QHGPDAIAAC QEHVMTGNIE GLLHEMIRLK EILERMPNAF
HSISPNPNAG DNYVSADKWV RWGLFSSPLS KRVPAASGLQ FPPYLVMDAF LGRKTHASFL
GVEALHLRAW LPSNHRAFIA AIQYHYSIPE FVQRSGDPRL MGVLEGIVEA YAGERGFMGV
HRYKVFGILE VAAKTGRTAT NGLSGAADAT RPWEETHRQF SDAMKERLEP FRGKLAMEPH
SMRGTFEECR YMAKIASCSS IDQDASRSTA MITLDIRDTG ITFAPGDRVA VMPLNSWEEC
AKMVAALGLD QHLREPVDTT GTWSRFEHHL STVTRTAHRQ LTVIDILRRG HLAPITKELT
VKVHELLHAS SNTVLQVLAT EEWPVRGSLG DLLQKAVLDT PSHIWNRAFN LEDLSWLSEL
VQLEVPRTYS ISSHSDELLP STVDLTISRA EYELSPIFSQ GQTVTRAGVA SGFFNPRPLS
AENSLLYEVL IGVSRPVAFQ LPIDKMVPCA FFAGGSGIAP FRSFWQHRLA TSGLSGGRNL
LYLGVQSREK FCYEAELREL VNMGFMEVHL AFSRDRHGLA YDGVARDLVE KPTPPRYIDS
LIVEQGNMIC DMVMSKKQGG LGGHLYVCGS VSVFDSVMSG IRKAMYNYRT ATMETVDLII
NKAFAERRFM LDVFMSPKAL PCNLPTISLS SLALHTGHRQ ESRMWIAVHG SVYDITDFCP
MHPGGTLIIK SNAGVDCTKS FDNLAHTNNP EVSSLLTRYF IGHLAPKPDY RDSDVSTLHD
LWASYLRVTV ETLVAHQFEM NDIMGESIDS PSAYDPNGIS NIWLREGLPN TIAIRTFYDY
QNRLLQGGFS ALFGSKLEEL VLRLSFNFAN SGGPGVASKL PDILGTIARA KSGSDAVRSA
KEISALGDFV CDPSSELRFQ ERGVLDFTAK CVQLDIELLE DLRQEACNGM DAFESIATVL
DSFDGSNSDS TPVAALSSFL LQTLERMAHR LAMFYTQLAR LSVYQPELEH NPARTRWAFV
RRCIRDGTFF VMTRSRNDGQ SMDGQSESYY INAKSLEKTT FDNILSQIKH VITSSTAESQ
TTIVQPSTVN DVHHERATTL AKDGSVASSA SRLNVGAVES MGSFMKKNEK AIRRLSSMPS
QLQLDDLQRA IALNDKPSPQ ASESTDASKE NPGRFKPLEL KTSLKIDPNA LLACKDQMLT
ARMRIMAGYE MMSCSASRLS APAKCTSISS ITFEEADELV VTNPQPLMEC LKSIPDDESV
PSSASCTTAQ SRRSSFSGSS VTGSIAESVI QTPPSRPYET SMALKLKLEG LNRRSRGESV
SSRQSFISAS SAMDLRRNRS LSSTRNASKR MSIDPGHTRE QSAGRLLAFK LGALAGERRS
FIPPTW
//
