ID A0A2H3H429_FUSOX Unreviewed; 1193 AA.
AC A0A2H3H429;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 13-SEP-2023, entry version 23.
DE RecName: Full=Ras guanine-nucleotide exchange protein Cdc25p {ECO:0008006|Google:ProtNLM};
GN ORFNames=AU210_010870 {ECO:0000313|EMBL:PCD31212.1};
OS Fusarium oxysporum f. sp. radicis-cucumerinum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=327505 {ECO:0000313|EMBL:PCD31212.1, ECO:0000313|Proteomes:UP000219602};
RN [1] {ECO:0000313|EMBL:PCD31212.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD31212.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=27387256; DOI=10.1111/1462-2920.13445;
RA van Dam P., Fokkens L., Schmidt S.M., Linmans J.H., Kistler H.C., Ma L.J.,
RA Rep M.;
RT "Effector profiles distinguish formae speciales of Fusarium oxysporum.";
RL Environ. Microbiol. 18:4087-4102(2016).
RN [2] {ECO:0000313|EMBL:PCD31212.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD31212.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=28831051; DOI=10.1038/s41598-017-07995-y;
RA van Dam P., Fokkens L., Ayukawa Y., van der Gragt M., Ter Horst A.,
RA Brankovics B., Houterman P.M., Arie T., Rep M.;
RT "A mobile pathogenicity chromosome in Fusarium oxysporum for infection of
RT multiple cucurbit species.";
RL Sci. Rep. 7:9042-9042(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCD31212.1}.
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DR EMBL; MABQ02000007; PCD31212.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3H429; -.
DR STRING; 327505.A0A2H3H429; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000219602; Chromosome 9.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000219602};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 69..135
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 720..840
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 899..1150
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1193 AA; 130948 MW; A0B3CE266F396FE0 CRC64;
MFSDQPMRAS LQVAPLTIAK SRTESSGDAS STSENDNTLY SQSQMTPPAT PNGSQEDLSP
SPQYIPPQVF HNFLRAFYPF NPSYVMSDSS VTLPLNEGDV ILVHSIHTNG WADGTLLVSG
ARGWLPTNYC EAYEPDDMCN LLKALLNFWD LLRSTSVNDK EIFGNQEFMK GIIAGVRFLL
ERTNCLNRES TFIQRNDALR KCRKSLLSEL SSLVKTAKRL QETQRLEIAP VEDVNDIIDE
MILKAFRIVT KGVRFMDVLE DDRRARAPSA VTVMDTVLEE SYVPPTPPAD QSSFDEQSQR
STSINDTDSQ AAASVAASES SETTQTSTSI FNKRLSSLSG RTGPSSHRLS QGSLSQAQAH
RLSATISHRV SLAGPSSVSR AHHLVTERLN RSHDTFLSHL GSFIGRLHLQ SQSRPELASA
IRQSALSGGE LLAVIDGVYD HINSSSEALA RARSTMFARI QDLVFSARDT LVSAASEDAD
LIMPHDNTML LASATGCVRA AGDCVAKAKS AIERIGDFEF ELETSSLGID LSILDIDTEE
RARTPSVSEH NDAVSVAGSN RTSNSSNGHA RRLTVVAIDK PLPEVPQVTT PTDEQTVHPS
PTSSRRSSVA DDNVSSLSTT LLANEEYSPV DNNDNDFNSS SRFDSMVASS AGSSATYLSR
DSEVSIVSQS STRATTPEQN LAPQKQPSLS NLSNGGSSED VDVESRLMEK TFAHELMFNK
EGQVTGGSLP ALVERLTTHE STPDAMFVST FYLTFRLFCT PVRLAEALIE RYDYVNDSPH
VAGPVRLRVY NAFKGWLESH WRDETDRDAL DLIIPFAEHK LASSLPSAGR RLFELAQRVS
GEGSLVPRLV SSMGKTNTSI AQYVPADTPL PIPAITKGQL NLLSAFKMGA AQPSILDFDP
LELARQLTIK QMNIFSSILP EELLASQWMK NGGVAAPNVK AMSSLSTDLS NLVAETILQQ
QEVKKRAQVI KQWIKIAHQC LELHNYDGLM AIICSLNSST ISRLRKTWDA ISTKRKDMLQ
NLQDLVEPSQ NNKVLRTRLH DHVPPCLPFL GMYLTDLTFV DIGNPATKQM CLGPESEEDG
NGGITVVNFD KHTRTAKIIG ELQRFQIPYR LTEVPDMQDW MSSQISHLRD SEEGNVQVTY
YRKSLLLEPR ETASRPPVDS SAASIVGVGG GRPDLFSWIS RDRGTSTPTP TQI
//