ID A0A2H3H508_FUSOX Unreviewed; 3935 AA.
AC A0A2H3H508;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AU210_005674 {ECO:0000313|EMBL:PCD37170.1};
OS Fusarium oxysporum f. sp. radicis-cucumerinum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=327505 {ECO:0000313|EMBL:PCD37170.1, ECO:0000313|Proteomes:UP000219602};
RN [1] {ECO:0000313|EMBL:PCD37170.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD37170.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=27387256; DOI=10.1111/1462-2920.13445;
RA van Dam P., Fokkens L., Schmidt S.M., Linmans J.H., Kistler H.C., Ma L.J.,
RA Rep M.;
RT "Effector profiles distinguish formae speciales of Fusarium oxysporum.";
RL Environ. Microbiol. 18:4087-4102(2016).
RN [2] {ECO:0000313|EMBL:PCD37170.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD37170.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=28831051; DOI=10.1038/s41598-017-07995-y;
RA van Dam P., Fokkens L., Ayukawa Y., van der Gragt M., Ter Horst A.,
RA Brankovics B., Houterman P.M., Arie T., Rep M.;
RT "A mobile pathogenicity chromosome in Fusarium oxysporum for infection of
RT multiple cucurbit species.";
RL Sci. Rep. 7:9042-9042(2017).
CC -!- PATHWAY: Mycotoxin biosynthesis. {ECO:0000256|ARBA:ARBA00004685}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCD37170.1}.
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DR EMBL; MABQ02000004; PCD37170.1; -; Genomic_DNA.
DR STRING; 327505.A0A2H3H508; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000219602; Chromosome 5.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000219602};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..435
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2382..2457
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3523..3600
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2469..2539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3935 AA; 433623 MW; 1B8830BE6335405C CRC64;
MSDNEPIAVI GSACRFPGDS SSPSKLWDLL KSPRDLLTKV PSNRYNADAF YHADSKHHGT
TNVRHSYFLN EDPARFDNNF FNIQPGEAEA IDPQQRLLME VVYQGLCASG QTIEGLRGSP
TAVYVGVMCD DWSGIITRDL EVFPQYGATG MARSIMSNRI SYFFDWHGPS MTIDTACSSS
LVAVHQAIQT LRSGESEVAI AAGANLILTP GMYVAESKLS MLSPSGRSKM WDQDVNGYAR
GEGIAAVVLK PLSAAIRDND HIDCIIRATG VNQDGRTPGL TMPSATAQAD LIRSTYARAG
LDINKPEDRP QFFHAHGTGT PAGDPREAEA IYRAFYSDVK DDKLYVGSIK TVLGHTEGTA
GLASLIGTAL AIQNKTIPPN MHFDVLNPKI KPFYDNLEVP TKAIAWPETK KGQPRRASIN
SFGFGGTNAH AIIEAYEPGT TDSAPGPLFS PLTFSASSES SLRSLLSSYS GYLKSNPELS
LKDLAYTLQT RRSTLAYRVA ITASDVEDVY TQLDAIENGE QSSTIGVRQV TKASPKIMGV
FTGQGAQWPR MGARLLEESA FASKRFSELD EALSSLPKDD RPSWALREMI IADAKSSRIA
EAAISQPLCT AVQVVLVDLL RQAGFELSGV VGHSSGEIGA AYAAGLLTAR DAIRVAYYRG
LYAKLAQSPN GCKGAMMAVG TTFDDASEFC ELDAFQGRIQ VAARNSSSSI TLSGDEDAIV
EAIETFKDEG KFARQLKVDT AYHSSHVLPC AKPYLEAMES CQIESATPTA TKWYSSVHDG
QVMTAELLTP QYWVDNMTSA VLFSPAVEHA WQEGGPYDLI IEVGPHPVLK TPCLDTLEDM
IGDRPPYSGV LGRGKDDIQQ FSNGLGFIWT QLGAGSVTFE RFEKVASDSK TVPSFIHDLP
NYPFDHARQF MSMSRVSGWY NSMQEAPHPI LGRRCHDRET SQTIQWRNVL NPKEIPWLHG
HQIQGQIIFP ATGYISMAVE AVNIIAESNL GLVTIEDLRI GRALAFSDDD ASVESMFDLR
IISRSEKEIE AEFSCYSGLP QNHTTSMVLN ATAHVKASLS VPTVHELPNI KVDDFNLREV
EVDRFYDFLG RLGYNYSWPF HGTTSIRRKA NFATGTLEDQ SGSEWEDQLL VHPGMLDTSL
QTTFAAFCCP GDERMWALHL PTSFRSIVIN PYFTSAGIGK QKSFQYQSVA IEERKASKVI
VELNLLSEET GDTFLQIEGM ELVPFSPATP ENDAVLFSRF DYRLASPDGE LTAAEYSFRD
EDYKMALDSE RIAFYYLRRL VETITPEEKA NTLPHYRHLV DWAAHVVPQV IDGRNPHIPS
SAQKDTHEDI QNILKKHYER VDVRLLESVG ENLPQVIRES GNILEHMTKD GMLDDVYEEG
FGLDLVNKYI AHMTAQIAHR YPRMNILEIG AGTGGSTREI LPRLGSAFST YTYTDVSGGF
FDTAQDRFQD FADRMIFKTF DMNISPGSQG FTEGTYDLVI ASNVLHATLE LEDMMKHVRS
FLKPGGFLII LETVNNDCLR VGLPMGSLPG WWLGAEHGRR WGPTLTLPQW DSLLWKCGFG
GIDTTTPPVH KILPGHVFCA QALDERVEIL RSPLSHLSDL PETKSTELAI VGGETLKVHR
MCEQISRRLK PKYASIARFN SIEELNTSGL ADSCTVVSLT ELDEPLFANM TSGKLDALKT
LWKQGGSILW VTSGARDENP HSYMTTGVGR CMRFEYPNIT LQALDIKAMT DRTPELIADH
LLRLELLDKW SKELRSEELL WSLEPEIYID DDTSIVPRLY PYESGNARYN AERRNVVKDA
NLETDRVIFA ENEGKWEVQH ASPLHIPREL PFAAKMKTIR ITHFSPATVN VTPGVSLMAC
VGIDTVSSER LLAATHIAES PVSVPADWCI PLGELDAVDT LANVSAFLIA SSILKHVATE
ETLVVHDAPS HLASALEGLA KESSVTVFLT TSDKANTKGW QYIDSHLPER VIKASIPRSA
TKFINLSQDV NAKETGRAIS ACLPRYCETI NAERLFESGK VIRQSVSKEE VSIVFNRAFY
EAKSLSSTAI DASLVSLKDI SGVSAAEVRF AVVDSKNSSV KASIRPIDDG RIFQADRTFL
LIGLSGELGQ SLCKWMVEQG ARNIVLTSRR PNVSQHFLDE MATMGATVKA LPMDVTNRDS
LHACVDTIQK TLPPIAGVVN GAMVLRDALF ENMPYEDFMK VLSPKVLGSQ LLDEMFYDTP
LDFFIFFSST TAVMGNSGQS NYIAGNMFMN ALAAQRKKRG VAASSIDISS IIGLGYVERA
EDLSEDTFIK MGYKPMSEQD LQKLFAEAIV LGRPECDEVC ELVTGVTPIY TDAQASDQYL
KDVKFGHFLM ERLDTQAYTG KTSTVPVRVQ LADVKTKADA VAIIKDSFIV RLRRVLAVGP
DEIINEKVTL VEQGVDSLMA VEVRSWFIKE LDVDIPVLKI LGGMSVPDLV EESLDLISDS
ILDVSSLEAG SAPTTQPIKP VLQTARVTPP ESSHGTSDES KQQTGSDSSR SPIDTPLTSM
ESQEPAKAED STDNSTPLKT FPNELSSIMS YGQAGFWFLN DYLINKKAFN MAVMLKLTGQ
IRVQALEKAV NLVAERHEIL RTRFFWGDDG DERTPLQGIN PADLKLTTKK VVDEGEAEME
LKKLHDEEWD LSGGEGVKIT LLSLSDNVHF LLLGMHHIYI DGYSFSVFFK DLEVAYTKHT
LPSLPVESQY RSFALQQRQM YANGDLTKSI EYYRRSFPKE FTPVGLFPFA LTPARQFAND
YSQHEAKMSI DPELATKVRQ LARVNRSTSF HVYLAALELL LFTLLPSAEE VFIGIADANR
SDKKFMGSLG FFLNLLPLRF GRKRRGTQLS SIIQTARDTA YGALQHSQLP FDVLLRELNV
PRSDKYTPIF QVFMDYRQVV QERSSWGGCK LHGEKWHNAV TGYDIALEVT ENITTDTLLS
MRLQKQLYSE EHTALLLRSY LSVLEYMVQG TNKAADAAPA WSKDDLQVAL DAGKAPEFLP
KWHSTISHHI DQIIQANATK VALKDGNGTV LTYEQMGKRI DSIAQALVDA GTTQGTVVGV
FQEPSSNWIC SLLAIFKAGA VYVPLDLRNS IPRLASIIKA SRPSLIITDH TTDDKVGLIG
AKFITKLQLS KLVEQEFKEP NRAKTGSLAV ILFTSGSTGE PKGLMMTHTN LMSYAEVSSK
TFSKPDENLV VLQQSPFSFD FSLDQTMAAL ANGGCLCIVP ASKRGDPDEI SKIMVKEGVT
YTTATPSEYD LWLRYSTSTL RQCISWKYAF SGGEAMSHKL AREFGTLNLA NLHVFNGYGP
AETTILSHRI DLKYTDPELP DPLPAGYPMP GFSVCIVDEK MRPVPLGVQG EIVLGGPCIV
SGYLNMPDST KDKFLPDTFF GTSGKVYRSG DRGRLCHDGL LFCDGRLEGS NMIKLRGFRV
ELDEVEKTII SHSAGALSHA VVTLRGSEEG RYLAAHVVFA PEFPEYNRES IMKTLRQTLP
LPPYMRPSAF QILADIPRTA HLKIDRKAIQ EMPVQVSDSH DSGALTIAEQ RLGELWRRVL
PLDPGSLSPE SDFFLIGGNS ILLVKLQALL RQTFETAPKL VALMGASTLG AMAIVLENCG
SVGVIDWDRE TALPDDLRGA ATLRPVRTTK DITVLLTGSA GYLGRHLLPA LVNDSRVTRV
HCLVRSVNNE KLSTSSSTKV RVIESDVSKP DLGLSASTYS RLAEETDVII HSAANRSFWD
RYEVLRPDNV DSVKELVRFA ASSGRSIPLH FLSSGAVKTY DGDGLTPPTD GSDGYVATKW
ASETFLRNAT GSIDLPVYTH RPTVSSTSQT KADQASIINE LISIVKSLGV RPSFEGVTGS
VDVLPIGDIV MTIQDSVLSS SAGGEGYNIV QHEAHQRAFV EDFAAVVRAD DTLNKLPSIS
ILDWFGKAKK AGFSYFLASQ DLVMGSGEGH LVSRR
//
