ID A0A2H3HE96_FUSOX Unreviewed; 1199 AA.
AC A0A2H3HE96;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=AU210_005796 {ECO:0000313|EMBL:PCD37294.1};
OS Fusarium oxysporum f. sp. radicis-cucumerinum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=327505 {ECO:0000313|EMBL:PCD37294.1, ECO:0000313|Proteomes:UP000219602};
RN [1] {ECO:0000313|EMBL:PCD37294.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD37294.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=27387256; DOI=10.1111/1462-2920.13445;
RA van Dam P., Fokkens L., Schmidt S.M., Linmans J.H., Kistler H.C., Ma L.J.,
RA Rep M.;
RT "Effector profiles distinguish formae speciales of Fusarium oxysporum.";
RL Environ. Microbiol. 18:4087-4102(2016).
RN [2] {ECO:0000313|EMBL:PCD37294.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD37294.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=28831051; DOI=10.1038/s41598-017-07995-y;
RA van Dam P., Fokkens L., Ayukawa Y., van der Gragt M., Ter Horst A.,
RA Brankovics B., Houterman P.M., Arie T., Rep M.;
RT "A mobile pathogenicity chromosome in Fusarium oxysporum for infection of
RT multiple cucurbit species.";
RL Sci. Rep. 7:9042-9042(2017).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCD37294.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MABQ02000004; PCD37294.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3HE96; -.
DR STRING; 327505.A0A2H3HE96; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000219602; Chromosome 5.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000219602}.
FT DOMAIN 1037..1053
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1199 AA; 134315 MW; 9E4E8196FC4C5699 CRC64;
MASQRSTAAR TPAKATKPAA TTSSAKQRSI VSFFQKAPPS SPAAAASSPL AKASPTTKQS
SCLKETTKAN SLPKTTPLSK SKPKPTVAIK QTTPVPDSDA IEHPSSQENF DSTMKVKNAP
KSAATRADTD RQKSSKMNHD ALPSSPTRKV KKVVSYAESS EEDEPFQFGG PASSHTMDDF
IASDSDEDTS RSKKRKRPSK PAAPRKRSNK SSPIPEPHID IKDSILEEDE LMDDVGGSTA
SQWSYDATST DKQPVVKPAE RVAMRDPKYK EKAHTKDPDQ RYPWLANIMD KDKRKPDHPE
YDKRTIYIPP AAWQKFSPFE TQYWKIKQNL WDTIVFFKKG KFYELYENDA TVGHQEFDFK
MTDRVNMRMV GVPESSLDHW VNQFIAKQYK VARVDQMETN LGKEMRERQD KSKKADKVIT
RELACILTAG TLVDGSMLQD DMASYCVAIK ESVVDDLPAF GIAFADTATG RFYLSTFVDD
VDLTKFETLI AQTGPRELLL EKSRLSTKAL RILKNNTSPT TIWTHLKPGD EFWEADKTRR
ELDCGGYFKA EDADEEVWPE ILQSLRDDDL AMSATGALIS YLRFLKLERP LLSQGNFELY
NPIQKNGTLI LDGQTLINLE VFSNSVNGGS EGTLFSLLNK CVTPFGKRLF RSWVAHPLCN
IDRINERLDA VEMLNADQTV REQFASQLVK MPDLERLISR IHAGACKPED FVKVLEGFEQ
IEYTMSLLGA YKGGNGLVDR LISSMPNLDE PLSYWRSAFD RSKARDEKLL IPERGIEEDF
DQSSDRIEEI KQQLEDLLAE KKKEFKCKLL KFTDVGKEIY QLEAPKSVKV PSTFRQMSAT
KDVKRWYFPE LSQLVRELQE AEETHSQLVR EVASRFFQKF DVDYETWLQA IKIISQLDCL
VSLAKASASL GQPSCRPEFV DEERSTVDFQ ELRHPCMMNT VDDFIPNDIK LGGDQAKINL
LTGANAAGKS TVLRMSCVAV IMAQIGCYVP ATFARLTPVD RIMSRLGAND NIFAAQSTFF
VELSETKKIL SEATPRSLVI LDELGRGTSS YDGVAVAQAV LHHVATHIGC VGYFATHYHS
LATEFENHPE IRARRMQIHV DDEERRVTFL YKLEDGVAEG SFGMHCAAMC GISSRVIDRA
EVAAKEWEHT SRLKDSLEKA KTGCYIPLGI LSDIGALLGD KGEMGDAAVD VLLNAIEAL
//
