ID A0A2H3HZG4_FUSOX Unreviewed; 509 AA.
AC A0A2H3HZG4;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Nuclear fusion protein KAR5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AU210_002447 {ECO:0000313|EMBL:PCD43349.1};
OS Fusarium oxysporum f. sp. radicis-cucumerinum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=327505 {ECO:0000313|EMBL:PCD43349.1, ECO:0000313|Proteomes:UP000219602};
RN [1] {ECO:0000313|EMBL:PCD43349.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD43349.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=27387256; DOI=10.1111/1462-2920.13445;
RA van Dam P., Fokkens L., Schmidt S.M., Linmans J.H., Kistler H.C., Ma L.J.,
RA Rep M.;
RT "Effector profiles distinguish formae speciales of Fusarium oxysporum.";
RL Environ. Microbiol. 18:4087-4102(2016).
RN [2] {ECO:0000313|EMBL:PCD43349.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD43349.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=28831051; DOI=10.1038/s41598-017-07995-y;
RA van Dam P., Fokkens L., Ayukawa Y., van der Gragt M., Ter Horst A.,
RA Brankovics B., Houterman P.M., Arie T., Rep M.;
RT "A mobile pathogenicity chromosome in Fusarium oxysporum for infection of
RT multiple cucurbit species.";
RL Sci. Rep. 7:9042-9042(2017).
CC -!- FUNCTION: Required for nuclear membrane fusion during karyogamy.
CC {ECO:0000256|ARBA:ARBA00003389, ECO:0000256|RuleBase:RU368082}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368082}. Nucleus membrane
CC {ECO:0000256|RuleBase:RU368082}.
CC -!- SIMILARITY: Belongs to the KAR5 family. {ECO:0000256|ARBA:ARBA00010473,
CC ECO:0000256|RuleBase:RU368082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCD43349.1}.
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DR EMBL; MABQ02000002; PCD43349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3HZG4; -.
DR OrthoDB; 2407997at2759; -.
DR Proteomes; UP000219602; Chromosome 2.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0048288; P:nuclear membrane fusion involved in karyogamy; IEA:UniProtKB-UniRule.
DR InterPro; IPR007292; Nuclear_fusion_Kar5.
DR PANTHER; PTHR28012; NUCLEAR FUSION PROTEIN KAR5; 1.
DR PANTHER; PTHR28012:SF1; NUCLEAR FUSION PROTEIN KAR5; 1.
DR Pfam; PF04163; Tht1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368082};
KW Karyogamy {ECO:0000256|ARBA:ARBA00022459, ECO:0000256|RuleBase:RU368082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|RuleBase:RU368082};
KW Reference proteome {ECO:0000313|Proteomes:UP000219602};
KW Signal {ECO:0000256|RuleBase:RU368082, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..509
FT /note="Nuclear fusion protein KAR5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013621882"
FT COILED 372..399
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 509 AA; 56524 MW; 10CF144DE530B489 CRC64;
MNMSSKAMSF FLLGVTFLTV FATEAHCFSW RPRPVDGHQV TLQHPQRSSD NSALLNKQSE
KRLSNVYNTA LQELQDLESE PLCHRIAARL LVNNCHLLDG QDDAKVHIDS GRAARDFVDS
YAASLAICDL ERGSFRIPVS CSKFRESTLA TLSASPIPQI HVSTVEIDEC LEGLAQSDSA
WNTWVSYRHK ALRFCDAARA DHQKDENILL YQKITKILEK LTRDIEADME ERFHSLNRAY
TAASQSVEDI GPHVRHLRTE MERASQILRD DLGRAAQDSR DVVESGLKET KVLHDLLELL
ARSVQEKTAD IVSSQEVAFQ TSTKQLNNEV DILMAVLSAA ISSSVSLQNQ VELTVSRNAD
ILEKQVKIEQ GMGKLEKLAE DLLVKYDNHE SRLDKAFRKT GQVLDILDAT AASATGLQSY
VFSSFGLSGV WPYIICPFLS LAMGSYGLQP SLVRNIWLVG FGELMGMVVS KADSYKDAFG
FPSTVETPDL TLNDTFSTSL AGESILKSV
//
