ID   A0A2H3I6R1_9EURO        Unreviewed;       517 AA.
AC   A0A2H3I6R1;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Winged helix-turn-helix transcription repressor DNA-binding {ECO:0000313|EMBL:PCG95544.1};
GN   ORFNames=PENO1_072960 {ECO:0000313|EMBL:PCG95544.1};
OS   Penicillium occitanis (nom. inval.).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=290292 {ECO:0000313|EMBL:PCG95544.1, ECO:0000313|Proteomes:UP000218381};
RN   [1] {ECO:0000313|EMBL:PCG95544.1, ECO:0000313|Proteomes:UP000218381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL100 {ECO:0000313|EMBL:PCG95544.1,
RC   ECO:0000313|Proteomes:UP000218381};
RX   PubMed=28951729; DOI=10.3389/fmicb.2017.01627;
RA   Bravo-Ruiz G., Sassi A.H., Marcet-Houben M., Di Pietro A., Gargouri A.,
RA   Gabaldon T., Roncero M.I.G.;
RT   "Regulatory Mechanisms of a Highly Pectinolytic Mutant of Penicillium
RT   occitanis and Functional Analysis of a Candidate Gene in the Plant Pathogen
RT   Fusarium oxysporum.";
RL   Front. Microbiol. 8:1627-1627(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PCG95544.1}.
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DR   EMBL; NPFK01000240; PCG95544.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H3I6R1; -.
DR   STRING; 290292.A0A2H3I6R1; -.
DR   OrthoDB; 1364107at2759; -.
DR   Proteomes; UP000218381; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd04450; DEP_RGS7-like; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10845; REGULATOR OF G PROTEIN SIGNALING; 1.
DR   PANTHER; PTHR10845:SF192; RGS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00049; DEP; 2.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000313|EMBL:PCG95544.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218381};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT   DOMAIN          212..301
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          347..489
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   REGION          320..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          497..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..341
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   517 AA;  58218 MW;  8EA1BFA517910580 CRC64;
     MSDTARKSAA RMLRTTDEDR PFTRDFKDLF STLMVSLELG ARRVRFTKVD FTFTMEEALN
     NLSSLRFTQS ARMPDPNDPS RIITTTSTTT FTMAKEMARN IFQNFIEARF LEPLNATFSS
     LSKGTVCTMT AKGIAVLHRF CNRNGITAPH VMRVLQSPRN KMTLLILERD LTTDKLVVDR
     ATIEVIFRRF AGVQAPGSIS GSPAWEDRTD YPNGLVGVEG MQDFRVNGRK YQYAFTGKAA
     INWLMDCCTT IDERETYRVC EQFIEHGLII SIVDDKSYID ENGQAALNFQ PTRQAVYSLT
     PRAMKVCGWA VSDRLSDESI NGKRDSKAAN NSTSSSNATG DVSNKSRLQY ILNDPSLRLL
     FREYLAASFC EENLAFYQDV TEYLDNYNKS KLSNELKDYH KLQDYIAGVF GLYNSFLAPG
     SPCELNIDHA LRNRLSSEMT GLSGDEQTVA RNLDEVVNLC QLAQVTIFKL MASDSVPKFC
     RQPRYAVILQ EHDFESISGN SSRPASPVSA PMRSAER
//