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Database: UniProt
Entry: A0A2H3I7R8_9EURO
LinkDB: A0A2H3I7R8_9EURO
Original site: A0A2H3I7R8_9EURO 
ID   A0A2H3I7R8_9EURO        Unreviewed;       604 AA.
AC   A0A2H3I7R8;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   10-APR-2019, entry version 4.
DE   SubName: Full=Peptidase S8/S53, subtilisin/kexin/sedolisin {ECO:0000313|EMBL:PCG91005.1};
GN   ORFNames=PENO1_096130 {ECO:0000313|EMBL:PCG91005.1};
OS   Penicillium sp. 'occitanis'.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=290292 {ECO:0000313|EMBL:PCG91005.1, ECO:0000313|Proteomes:UP000218381};
RN   [1] {ECO:0000313|EMBL:PCG91005.1, ECO:0000313|Proteomes:UP000218381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL100 {ECO:0000313|EMBL:PCG91005.1,
RC   ECO:0000313|Proteomes:UP000218381};
RX   PubMed=28951729; DOI=10.3389/fmicb.2017.01627;
RA   Bravo-Ruiz G., Sassi A.H., Marcet-Houben M., Di Pietro A.,
RA   Gargouri A., Gabaldon T., Roncero M.I.G.;
RT   "Regulatory Mechanisms of a Highly Pectinolytic Mutant of Penicillium
RT   occitanis and Functional Analysis of a Candidate Gene in the Plant
RT   Pathogen Fusarium oxysporum.";
RL   Front. Microbiol. 8:1627-1627(2017).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PCG91005.1}.
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DR   EMBL; NPFK01000446; PCG91005.1; -; Genomic_DNA.
DR   Proteomes; UP000218381; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000218381};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218381};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    604       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013890929.
FT   DOMAIN      211    604       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    286    286       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    290    290       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    504    504       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       546    546       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       547    547       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       582    582       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       584    584       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   604 AA;  63637 MW;  0EC790D86B39F13B CRC64;
     MSRNLLVGAG LLTLAQLNPV LAASALVSHE SLAALPSGWS QVGTPAADTN IQLSVGLTLE
     NIEQLESHLQ SVSTPGSASY GQYLDSDDIA AQYGPSDASV EAVTNWLNEA GITEVYNNGQ
     SIHFGTTVSK ANSLLGADFN YYSDGGSTKL RTLAYSVPSD LKAAIDLVSP TTYFGKTTAS
     RSIQTYKNKR ASTTTTSSSS SVSVAASCQT SITPACLKQI YNVGNYTPRV ASGSRVGFGS
     FLNQSAIFDD LFTYEKVNGI PSQNFTKVII ANAPNDQNPN DGNYGEANLD VQNIVGISHP
     LPVTEFLTGG SPPFIPSLDT PTDENEPYIP YYEYLLSQKN DDLPQVISNS YGDDEQSVPY
     KYAVRACNLI GLTGLRGITV LESSGDLGVG AGCLSNDGKN KTQFDAIFPA TCPYLTAVGG
     TQAVTPEIAW TASSGGFSYY FPRAWYQEGA IETYLGLLDD STKEYYSQYT NFEGRGFPDV
     AAHSLLPDYQ VVGGGELQPS GGTSAASPVF AGIIALLNDA RLSAGKPTLG FLNPFIYFSG
     YRGLNDITGG QSVGCNGING QTGQPVVGGG VVPGAAWNCT TGWDPATGLG TPDFQKLKDL
     VLSF
//
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